X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) is inherited through mutations in EMD, which encodes a nuclear membrane protein named emerin. Emerin is expressed in most cells, but EDMD strikes specific tissues. This review summarizes growing evidence that emerin has roles in both tissue-specific gene regulation and the mechanical integrity of the nucleus and discusses how these roles might impact EDMD.
|Original language||English (US)|
|Number of pages||5|
|Journal||Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology|
|State||Published - Jul 2006|
All Science Journal Classification (ASJC) codes
- Agricultural and Biological Sciences (miscellaneous)