Multiple roles for emerin: Implications for Emery-Dreifuss muscular dystrophy

James M. Holaska, Katherine L. Wilson

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) is inherited through mutations in EMD, which encodes a nuclear membrane protein named emerin. Emerin is expressed in most cells, but EDMD strikes specific tissues. This review summarizes growing evidence that emerin has roles in both tissue-specific gene regulation and the mechanical integrity of the nucleus and discusses how these roles might impact EDMD.

Original languageEnglish (US)
Pages (from-to)676-680
Number of pages5
JournalAnatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology
Volume288
Issue number7
DOIs
StatePublished - Jul 1 2006

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Agricultural and Biological Sciences (miscellaneous)

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