Abstract
X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) is inherited through mutations in EMD, which encodes a nuclear membrane protein named emerin. Emerin is expressed in most cells, but EDMD strikes specific tissues. This review summarizes growing evidence that emerin has roles in both tissue-specific gene regulation and the mechanical integrity of the nucleus and discusses how these roles might impact EDMD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 676-680 |
| Number of pages | 5 |
| Journal | Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology |
| Volume | 288 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2006 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Anatomy
- Agricultural and Biological Sciences (miscellaneous)