TY - JOUR
T1 - Molecular imprinting within hydrogels II
T2 - Progress and analysis of the field
AU - Byrne, Mark E.
AU - Salian, Vishal
N1 - Funding Information:
This work was supported by a grant from the National Science Foundation (NSF-CBET-0730903, Grant G00003191). We thank Siddarth Venkatesh for reading the manuscript, discussion, and providing critical comment. We also thank Huong Thi Thu Ngo for producing electronic figures from drawings and Jishnu Saha for aid during the extensive literature search.
PY - 2008/12/8
Y1 - 2008/12/8
N2 - In the past decade, there has been an exponential increase in the number of papers describing molecular imprinting in hydrogels, a technique which creates memory for template molecules within a flexible macromolecular structure. Macromolecular memory or structural plasticity of polymer chains is a superior description of weakly crosslinked imprinted networks since significant flexibility can occur within the polymer chains. The focus of this article is to review and highlight work in the field describing the imprinting strategy within hydrogels and associated challenges, characterization methods of imprinted gels, current and potential translational applications, and future strategies and directions. This paper also describes ways to improve binding parameter efficacy and presents significant areas of opportunity to further describe, characterize, and understand imprinted gels. An analysis of the literature indicates that imprinting in hydrogels leads to significant improvements in template affinity, capacity, and selectivity over non-templated hydrogels for a number of templates such as ions, small and moderate molecular weight molecules, proteins, viruses, DNA, and cells. However, the influence of imprinting on the transport of template is much more complex, with little attention of most studies to structural analysis or discussion of the gel porosity/tortuosity in the control of template transport. Responsive, intelligent imprinted hydrogels are also highlighted that exhibit reversibly modulated template binding and transport. It is clear that this field has transitioned from infancy and is leading to breakthroughs in a number of areas such as controlled and modulated drug delivery, diagnostic sensors, and separation. For example in drug delivery, imprinting can lead to delayed transport and provides further control of therapeutic transport through the macromolecular structure as well as optimizes the number of therapeutic molecules to polymer chains.
AB - In the past decade, there has been an exponential increase in the number of papers describing molecular imprinting in hydrogels, a technique which creates memory for template molecules within a flexible macromolecular structure. Macromolecular memory or structural plasticity of polymer chains is a superior description of weakly crosslinked imprinted networks since significant flexibility can occur within the polymer chains. The focus of this article is to review and highlight work in the field describing the imprinting strategy within hydrogels and associated challenges, characterization methods of imprinted gels, current and potential translational applications, and future strategies and directions. This paper also describes ways to improve binding parameter efficacy and presents significant areas of opportunity to further describe, characterize, and understand imprinted gels. An analysis of the literature indicates that imprinting in hydrogels leads to significant improvements in template affinity, capacity, and selectivity over non-templated hydrogels for a number of templates such as ions, small and moderate molecular weight molecules, proteins, viruses, DNA, and cells. However, the influence of imprinting on the transport of template is much more complex, with little attention of most studies to structural analysis or discussion of the gel porosity/tortuosity in the control of template transport. Responsive, intelligent imprinted hydrogels are also highlighted that exhibit reversibly modulated template binding and transport. It is clear that this field has transitioned from infancy and is leading to breakthroughs in a number of areas such as controlled and modulated drug delivery, diagnostic sensors, and separation. For example in drug delivery, imprinting can lead to delayed transport and provides further control of therapeutic transport through the macromolecular structure as well as optimizes the number of therapeutic molecules to polymer chains.
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U2 - 10.1016/j.ijpharm.2008.09.002
DO - 10.1016/j.ijpharm.2008.09.002
M3 - Review article
C2 - 18824226
AN - SCOPUS:55849122994
SN - 0378-5173
VL - 364
SP - 188
EP - 212
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 2
ER -