MiRNA 146a-5p-loaded poly(d,l-lactic-co-glycolic acid) nanoparticles impair pain behaviors by inhibiting multiple inflammatory pathways in microglia

Thuỳ Linh Pham; Yuhua Yin; Hyeok Hee Kwon; Nara Shin; Song I. Kim; Hyewon Park; Juhee Shin; Hyo Jung Shin; Jeong Ah Hwang; Hee Jung Song; Sang Ryong Kim; Joo Hyoung Lee; Patrick T.J. Hwang; Ho Wook Jun; Dong Woon Kim

doi:10.2217/nnm-2019-0462

MiRNA 146a-5p-loaded poly(d,l-lactic-co-glycolic acid) nanoparticles impair pain behaviors by inhibiting multiple inflammatory pathways in microglia

Thuỳ Linh Pham, Yuhua Yin, Hyeok Hee Kwon, Nara Shin, Song I. Kim, Hyewon Park, Juhee Shin, Hyo Jung Shin, Jeong Ah Hwang, Hee Jung Song, Sang Ryong Kim, Joo Hyoung Lee, Patrick T.J. Hwang, Ho Wook Jun, Dong Woon Kim

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22 Scopus citations

Abstract

Aims: We investigated whether miRNA (miR) 146a-5p-loaded nanoparticles (NPs) can attenuate neuropathic pain behaviors in the rat spinal nerve ligation-induced neuropathic pain model by inhibiting activation of the NF-κB and p38 MAPK pathways in spinal microglia. Materials & methods: After NP preparation, miR NPs were assessed for their physical characteristics and then injected intrathecally into the spinal cords of rat spinal nerve ligation rats to test their analgesic effects. Results: miR NPs reduced pain behaviors for 11 days by negatively regulating the inflammatory response in spinal microglia. Conclusion: The anti-inflammatory effects of miR 146a-5p along with nanoparticle-based materials make miR NPs promising tools for treating neuropathic pain.

Original language	English (US)
Pages (from-to)	1113-1126
Number of pages	14
Journal	Nanomedicine
Volume	15
Issue number	11
DOIs	https://doi.org/10.2217/nnm-2019-0462
State	Published - May 2020
Externally published	Yes

All Science Journal Classification (ASJC) codes

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
General Materials Science
Development

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Pham, T. L., Yin, Y., Kwon, H. H., Shin, N., Kim, S. I., Park, H., Shin, J., Shin, H. J., Hwang, J. A., Song, H. J., Kim, S. R., Lee, J. H., Hwang, P. T. J., Jun, H. W., & Kim, D. W. (2020). MiRNA 146a-5p-loaded poly(d,l-lactic-co-glycolic acid) nanoparticles impair pain behaviors by inhibiting multiple inflammatory pathways in microglia. Nanomedicine, 15(11), 1113-1126. https://doi.org/10.2217/nnm-2019-0462

@article{8479048357764e3c896e451562c78ab9,

title = "MiRNA 146a-5p-loaded poly(d,l-lactic-co-glycolic acid) nanoparticles impair pain behaviors by inhibiting multiple inflammatory pathways in microglia",

abstract = "Aims: We investigated whether miRNA (miR) 146a-5p-loaded nanoparticles (NPs) can attenuate neuropathic pain behaviors in the rat spinal nerve ligation-induced neuropathic pain model by inhibiting activation of the NF-κB and p38 MAPK pathways in spinal microglia. Materials & methods: After NP preparation, miR NPs were assessed for their physical characteristics and then injected intrathecally into the spinal cords of rat spinal nerve ligation rats to test their analgesic effects. Results: miR NPs reduced pain behaviors for 11 days by negatively regulating the inflammatory response in spinal microglia. Conclusion: The anti-inflammatory effects of miR 146a-5p along with nanoparticle-based materials make miR NPs promising tools for treating neuropathic pain.",

author = "Pham, {Thuỳ Linh} and Yuhua Yin and Kwon, {Hyeok Hee} and Nara Shin and Kim, {Song I.} and Hyewon Park and Juhee Shin and Shin, {Hyo Jung} and Hwang, {Jeong Ah} and Song, {Hee Jung} and Kim, {Sang Ryong} and Lee, {Joo Hyoung} and Hwang, {Patrick T.J.} and Jun, {Ho Wook} and Kim, {Dong Woon}",

note = "Publisher Copyright: {\textcopyright} 2020 Dong Woon Kim.",

year = "2020",

month = may,

doi = "10.2217/nnm-2019-0462",

language = "English (US)",

volume = "15",

pages = "1113--1126",

journal = "Nanomedicine",

issn = "1743-5889",

publisher = "Future Medicine Ltd.",

number = "11",

}

Pham, TL, Yin, Y, Kwon, HH, Shin, N, Kim, SI, Park, H, Shin, J, Shin, HJ, Hwang, JA, Song, HJ, Kim, SR, Lee, JH, Hwang, PTJ, Jun, HW & Kim, DW 2020, 'MiRNA 146a-5p-loaded poly(d,l-lactic-co-glycolic acid) nanoparticles impair pain behaviors by inhibiting multiple inflammatory pathways in microglia', Nanomedicine, vol. 15, no. 11, pp. 1113-1126. https://doi.org/10.2217/nnm-2019-0462

TY - JOUR

T1 - MiRNA 146a-5p-loaded poly(d,l-lactic-co-glycolic acid) nanoparticles impair pain behaviors by inhibiting multiple inflammatory pathways in microglia

AU - Pham, Thuỳ Linh

AU - Yin, Yuhua

AU - Kwon, Hyeok Hee

AU - Shin, Nara

AU - Kim, Song I.

AU - Park, Hyewon

AU - Shin, Juhee

AU - Shin, Hyo Jung

AU - Hwang, Jeong Ah

AU - Song, Hee Jung

AU - Kim, Sang Ryong

AU - Lee, Joo Hyoung

AU - Hwang, Patrick T.J.

AU - Jun, Ho Wook

AU - Kim, Dong Woon

PY - 2020/5

Y1 - 2020/5

N2 - Aims: We investigated whether miRNA (miR) 146a-5p-loaded nanoparticles (NPs) can attenuate neuropathic pain behaviors in the rat spinal nerve ligation-induced neuropathic pain model by inhibiting activation of the NF-κB and p38 MAPK pathways in spinal microglia. Materials & methods: After NP preparation, miR NPs were assessed for their physical characteristics and then injected intrathecally into the spinal cords of rat spinal nerve ligation rats to test their analgesic effects. Results: miR NPs reduced pain behaviors for 11 days by negatively regulating the inflammatory response in spinal microglia. Conclusion: The anti-inflammatory effects of miR 146a-5p along with nanoparticle-based materials make miR NPs promising tools for treating neuropathic pain.

AB - Aims: We investigated whether miRNA (miR) 146a-5p-loaded nanoparticles (NPs) can attenuate neuropathic pain behaviors in the rat spinal nerve ligation-induced neuropathic pain model by inhibiting activation of the NF-κB and p38 MAPK pathways in spinal microglia. Materials & methods: After NP preparation, miR NPs were assessed for their physical characteristics and then injected intrathecally into the spinal cords of rat spinal nerve ligation rats to test their analgesic effects. Results: miR NPs reduced pain behaviors for 11 days by negatively regulating the inflammatory response in spinal microglia. Conclusion: The anti-inflammatory effects of miR 146a-5p along with nanoparticle-based materials make miR NPs promising tools for treating neuropathic pain.

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MiRNA 146a-5p-loaded poly(d,l-lactic-co-glycolic acid) nanoparticles impair pain behaviors by inhibiting multiple inflammatory pathways in microglia

Abstract

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