Abstract
The thrust of this report is to stress the importance of microheterogeneities in the microenvironment of differentiating tissues as a possible inducer or regulator of differentiation. During chondrogenesis both qualitative and quantitative changes occur in the proteoglycan population. Using molecular sieve chromatography, these changes can be characterized and used as indices of differentiation. Microheterogeneities of the extracellular matrix may be an example of 'non equivalence' as a regulatory device for differentiation.
Original language | English (US) |
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Pages (from-to) | 333-338 |
Number of pages | 6 |
Journal | Medical Biology |
Volume | 56 |
Issue number | 6 |
State | Published - 1978 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- General Medicine