Microcirculatory Dysfunction in Sepsis

David J. Lundy; Stephen Trzeciak

doi:10.1016/j.ccc.2009.06.002

Microcirculatory Dysfunction in Sepsis

David J. Lundy, Stephen Trzeciak

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Abstract

This article discusses the role of microcirculatory dysfunction in the pathophysiology of sepsis, reviewing the role of the endothelium in modulating microcirculatory flow, discussing the function of nitric oxide in mediating microcirculatory blood flow, and outlining means of evaluating microcirculatory function in septic patients. Finally, potential novel therapies and challenges in treating microcirculatory dysfunction in septic patients are discussed.

Original language	English (US)
Pages (from-to)	721-731
Number of pages	11
Journal	Critical Care Clinics
Volume	25
Issue number	4
DOIs	https://doi.org/10.1016/j.ccc.2009.06.002
State	Published - Oct 2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

Critical Care and Intensive Care Medicine

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10.1016/j.ccc.2009.06.002

Cite this

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title = "Microcirculatory Dysfunction in Sepsis",

abstract = "This article discusses the role of microcirculatory dysfunction in the pathophysiology of sepsis, reviewing the role of the endothelium in modulating microcirculatory flow, discussing the function of nitric oxide in mediating microcirculatory blood flow, and outlining means of evaluating microcirculatory function in septic patients. Finally, potential novel therapies and challenges in treating microcirculatory dysfunction in septic patients are discussed.",

author = "Lundy, \{David J.\} and Stephen Trzeciak",

year = "2009",

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doi = "10.1016/j.ccc.2009.06.002",

language = "English (US)",

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issn = "0749-0704",

publisher = "W.B. Saunders",

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T1 - Microcirculatory Dysfunction in Sepsis

AU - Lundy, David J.

AU - Trzeciak, Stephen

PY - 2009/10

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N2 - This article discusses the role of microcirculatory dysfunction in the pathophysiology of sepsis, reviewing the role of the endothelium in modulating microcirculatory flow, discussing the function of nitric oxide in mediating microcirculatory blood flow, and outlining means of evaluating microcirculatory function in septic patients. Finally, potential novel therapies and challenges in treating microcirculatory dysfunction in septic patients are discussed.

AB - This article discusses the role of microcirculatory dysfunction in the pathophysiology of sepsis, reviewing the role of the endothelium in modulating microcirculatory flow, discussing the function of nitric oxide in mediating microcirculatory blood flow, and outlining means of evaluating microcirculatory function in septic patients. Finally, potential novel therapies and challenges in treating microcirculatory dysfunction in septic patients are discussed.

UR - https://www.scopus.com/pages/publications/70350502829

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U2 - 10.1016/j.ccc.2009.06.002

DO - 10.1016/j.ccc.2009.06.002

M3 - Review article

C2 - 19892249

AN - SCOPUS:70350502829

SN - 0749-0704

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SP - 721

EP - 731

JO - Critical Care Clinics

JF - Critical Care Clinics

IS - 4

ER -

Microcirculatory Dysfunction in Sepsis

Abstract

All Science Journal Classification (ASJC) codes

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