Mechanobiology of Cardiac Fibroblasts

Peter A. Galie, Jan P. Stegemann

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The healthy myocardium contains cardiomyocytes, mast cells, fibroblasts, and other vascular cell types. Cardiac fibroblasts constitute the largest cell population in the heart and therefore understanding how these cells function is essential for studying heart disease. Recent research has focused on how cardiac fibroblasts affect a broad range of cardiac pathologies: arrhythmias, dilated cardiomyopathy, cardiac hypertrophy, and other systolic- and diastolic-related diseases. In order to understand how cardiac fibroblasts contribute to these various disease states, it is necessary to learn how these cells respond to changes in biochemical and mechanical stimuli. Both have important impact on cell function, and this chapter focuses primarily on the effect of the mechanical environment. In addition, it addresses relevant biochemical factors, since the mechanical and biochemical environments are intimately linked. The process by which cells transduce mechanical signals into a biological response has been termed mechanobiology. The mechanobiology of cardiac fibroblasts has been the subject of extensive research in recent years, the results of which have had direct implications for the treatment of heart disease. This chapter provides an overview of the mechanical forces present in the myocardium, the cardiac fibroblast phenotype, and presents key recent results in the area of cardiac fibroblast mechanobiology.

Original languageEnglish (US)
Title of host publicationMechanobiology Handbook
Subtitle of host publicationSecond Edition
PublisherCRC Press
Pages229-240
Number of pages12
ISBN (Electronic)9780429816741
ISBN (Print)9781498779463
DOIs
StatePublished - Jan 1 2018

All Science Journal Classification (ASJC) codes

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology
  • General Engineering

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