Longitudinal patterns of semantic and episodic memory in frontotemporal lobar degeneration and Alzheimers disease

Sharon X. Xie, David J. Libon, Xingmei Wang, Lauren Massimo, Peachie Moore, Luisa Vesely, Alea Khan, Anjan Chatterjee, H. Branch Coslett, Howard I. Hurtig, Tsao Wei Liang, Murray Grossman

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The longitudinal assessment of episodic and semantic memory was obtained from 236 patients diagnosed with Alzheimers disease (AD, n = 128) and with frontotemporal lobar degeneration (FTLD, n = 108), including patients with a social comportment/dysexecutive (SOC/EXEC) disorder, progressive nonfluent aphasia (PNFA), semantic dementia (SemD), and corticobasal syndrome (CBS). At the initial assessment, AD patients obtained a lower score on the delayed free recall test than other patients. Longitudinal analyses for delayed free recall found converging performance, with all patients reaching the same level of impairment as AD patients. On the initial evaluation for delayed recognition, AD patients also obtained lower scores than other groups. Longitudinal analyses for delayed recognition test performance found that AD patients consistently produced lower scores than other groups and no convergence between AD and other dementia groups was seen. For semantic memory, there were no initial between-group differences. However, longitudinal analyses for semantic memory revealed group differences over illness duration, with worse performance for SemD versus AD, PNFA, SOC/EXEC, and CBS patients. These data suggest the presence of specific longitudinal patterns of impairment for episodic and semantic memory in AD and FTLD patients suggesting that all forms of dementia do not necessarily converge into a single phenotype.

Original languageEnglish (US)
Pages (from-to)278-286
Number of pages9
JournalJournal of the International Neuropsychological Society
Issue number2
StatePublished - Mar 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health


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