Liquid membrane oxygenator

H. W. Wallace, W. J. Asher, M. T. Zubrow, T. P. Stein, H. Brooks, W. S. Blakemore

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A method of blood oxygenation is presented which uses liquid membranes made of fluorochemical to encapsulate oxygen bubbles, thus preventing a blood gas interface. Whether contact with fluorochemical will induce serious alterations in blood was investigated by means of a unique interface generator. No significant alterations were noted in human whole blood during a 24 hr period of continuous blood fluorochemical interface generation in vitro. Six dogs underwent veno venous perfusion with the interface generator, resulting in continuous contact of their blood with fluorochemical over a 4 hr period. They were followed for up to 53 days after the experimentation, and no chemical or pathological alterations were noted. No contamination of blood by fluorochemical was detected in either the in vitro or the in vivo experiments. Preliminary evaluation of a prototype liquid membrane oxygenator used during heart lung bypass in 2 dogs is reported.

Original languageEnglish (US)
Pages (from-to)887-893
Number of pages7
JournalUnknown Journal
Issue number6
StatePublished - 1973
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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