Bioactive derivatives of polyunsaturated fatty acids (most importantly, arachidonic acid, EPA, and DHA) regulate essential aspects of lung function. These mediators include prostaglandins, isoprostanes, leukotrienes, lipoxins, and resolvins. They exert synergistic and opposing effects on bronchial constriction and relaxation, pulmonary vascular tone, and/or the initiation and cessation of immune and inflammatory responses in the lung. The identification in lung tissues of specific receptors for these mediators, as well as the lipid-responsive PPAR-α and PPAR-γ transcription factors, suggests that they are important in maintaining lung homeostasis. Several fatty acid-derived mediators (or their synthetic agonists or antagonists) have demonstrated therapeutic value in correcting derangements of lung function in asthma, pulmonary hypertension, inflammatory lung disease, fibrosis, or acute lung injury.
|Original language||English (US)|
|Title of host publication||Comparative Biology of the Normal Lung|
|Subtitle of host publication||Second Edition|
|Number of pages||19|
|State||Published - Mar 18 2015|
All Science Journal Classification (ASJC) codes
- Pharmacology, Toxicology and Pharmaceutics(all)