Light-responsive polymeric micellar nanoparticles with enhanced formulation stability

Kyoung Nan Kim, Keun Sang Oh, Jiwook Shim, Isabel R. Schlaepfer, Sana D. Karam, Jung Jae Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Light-sensitive polymeric micelles have recently emerged as promising drug delivery systems for spatiotemporally controlled release of payload at target sites. Here, we developed diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles that showed a change in polarity of the micellar core from hydrophobic to hydrophilic under UV light, releasing the encapsulated anticancer drug, doxetaxel (DTX). The micelles exhibited a low critical micelle concentration and high stability in the presence of bovine serum albumin (BSA) solution due to the hydrophobic and stacking interactions in the micellar core. Cell studies showed enhanced cytotoxicity of DTX-loaded micellar nanoparticles upon irradiation. The enhanced stability would increase the circulation time of the micellar nanoparticles in blood, and enhance the therapeutic effectiveness for cancer therapy.

Original languageEnglish (US)
Article number377
Pages (from-to)1-11
Number of pages11
JournalPolymers
Volume13
Issue number3
DOIs
StatePublished - 2021

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Polymers and Plastics

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