Life cycle analysis of solvent reduction in pharmaceutical synthesis using continuous adsorption for palladium removal

C. Stewart Slater, Mariano J. Savelski, Marie Nydia Ruiz-Felix

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The life cycle emissions associated with the reduction of wastes from an adsorption process to remove palladium complexes in drug manufacture have been evaluated. The study assessed a green improvement to a process step in an active pharmaceutical ingredient synthesis where palladium catalyst is removed from a reaction mixture. The greener process uses a continuous adsorption system, composed of a more efficient adsorbent, consuming less organic solvent and rinse water, which results in less waste disposal. The newer process is also more energy and cost efficient from an operational perspective. There is a 94% reduction in the carbon footprint of the new process when compared to the current operation.

Original languageEnglish (US)
Pages (from-to)1602-1608
Number of pages7
JournalJournal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering
Volume48
Issue number13
DOIs
StatePublished - Nov 10 2013

All Science Journal Classification (ASJC) codes

  • Environmental Engineering

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