TY - JOUR
T1 - Life cycle analysis of solvent reduction in pharmaceutical synthesis using continuous adsorption for palladium removal
AU - Slater, C. Stewart
AU - Savelski, Mariano J.
AU - Ruiz-Felix, Marie Nydia
N1 - Funding Information:
Partial support for this has been provided by a grant from the US Environmental Protection Agency, NP 97257006-0. The authors wish to acknowledge Novartis Pharmaceutical Corporation for their support and Thomas Blacklock and Michael Girgis for their assistance.
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/11/10
Y1 - 2013/11/10
N2 - The life cycle emissions associated with the reduction of wastes from an adsorption process to remove palladium complexes in drug manufacture have been evaluated. The study assessed a green improvement to a process step in an active pharmaceutical ingredient synthesis where palladium catalyst is removed from a reaction mixture. The greener process uses a continuous adsorption system, composed of a more efficient adsorbent, consuming less organic solvent and rinse water, which results in less waste disposal. The newer process is also more energy and cost efficient from an operational perspective. There is a 94% reduction in the carbon footprint of the new process when compared to the current operation.
AB - The life cycle emissions associated with the reduction of wastes from an adsorption process to remove palladium complexes in drug manufacture have been evaluated. The study assessed a green improvement to a process step in an active pharmaceutical ingredient synthesis where palladium catalyst is removed from a reaction mixture. The greener process uses a continuous adsorption system, composed of a more efficient adsorbent, consuming less organic solvent and rinse water, which results in less waste disposal. The newer process is also more energy and cost efficient from an operational perspective. There is a 94% reduction in the carbon footprint of the new process when compared to the current operation.
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U2 - 10.1080/10934529.2013.815080
DO - 10.1080/10934529.2013.815080
M3 - Article
C2 - 23947697
AN - SCOPUS:84883576744
VL - 48
SP - 1602
EP - 1608
JO - Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering
JF - Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering
SN - 1093-4529
IS - 13
ER -