Leukotriene E4 and granulocytic infiltration into asthmatic airways

L. A. Laitinen, T. Haahtela, V. Vilkka, T. H. Lee, B. W. Spur

Research output: Contribution to journalArticlepeer-review

487 Scopus citations

Abstract

Sulphidopeptide leukotrienes are potent bronchoconstrictors and increase bronchial hyperreactivity, one of the hallmarks of asthma. We have demonstrated that leukotriene LTE4, the most stable of the sulphidopeptide leukotrienes, elicited an increase in the numbers of eosinophils and neutrophils in the lamina propria of the airway mucosa 4 h after inhalation in 4 asthmatic subjects. The numbers of eosinophils were, on average, 10-fold greater than those of neutrophils. There was no significant change in numbers of lymphocytes, plasma cells, mast cells, or macrophages. Since LTE4 recruits granulocytes, the potential of antisulphidopeptide leukotriene drugs as antiinflammatory and "steroid-sparing" agents should be tested.

Original languageEnglish (US)
Pages (from-to)989-990
Number of pages2
JournalThe Lancet
Volume341
Issue number8851
DOIs
StatePublished - Apr 17 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine

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