TY - JOUR
T1 - Leukoaraiosis severity and list-learning in dementia
AU - Price, Catherine C.
AU - Garrett, Kelly Davis
AU - Jefferson, Angela L.
AU - Cosentino, Stephanie
AU - Tanner, Jared J.
AU - Penney, Dana L.
AU - Swenson, Rodney
AU - Giovannetti, Tania
AU - Bettcher, Brianne Magouirk
AU - Libon, David J.
N1 - Funding Information:
We wish to thank the editor (JS) and reviewers for their insightful and constructive comments/suggestions. This research was supported in part by the following NIH grants: K23NS060660_01 (CCP) and F32-AG021362 (CCP); R03-AG026610 (ALJ), R03-AG027480 (ALJ), K23-AG030962 (Paul B. Beeson Career Development Award in Aging; ALJ), and P30-AG013846 (Boston University Alzheimer’s Disease Core Center; ALJ). Portions of this research were presented at the 3rd Biannual Meeting of the International Society for Vascular Behavioural and Cognitive Disorders, San Antonio, TX. No authors have conflicts of interest to report.
PY - 2009/8
Y1 - 2009/8
N2 - In patients with dementia, leukoaraiosis (LA) was hypothesized to result in differential patterns of impairment on a verbal serial list-learning test. Using a visual rating scale, 144 dementia patients with ischemic scores 4 were re-categorized as having mild (n = 73), moderate (n = 44), or severe LA (n = 27). Mild LA was predicted to be associated with an amnestic list-learning profile, while severe LA was predicted to be associated with a dysexecutive profile. List-learning performances were standardized to a group of healthy older adults (n = 24). Analyses were conducted on a set of four factors derived from the list-learning paradigm, as well as error scores. Data indicate that LA severity is an important marker for understanding list learning in dementia.
AB - In patients with dementia, leukoaraiosis (LA) was hypothesized to result in differential patterns of impairment on a verbal serial list-learning test. Using a visual rating scale, 144 dementia patients with ischemic scores 4 were re-categorized as having mild (n = 73), moderate (n = 44), or severe LA (n = 27). Mild LA was predicted to be associated with an amnestic list-learning profile, while severe LA was predicted to be associated with a dysexecutive profile. List-learning performances were standardized to a group of healthy older adults (n = 24). Analyses were conducted on a set of four factors derived from the list-learning paradigm, as well as error scores. Data indicate that LA severity is an important marker for understanding list learning in dementia.
UR - https://www.scopus.com/pages/publications/68949164878
UR - https://www.scopus.com/pages/publications/68949164878#tab=citedBy
U2 - 10.1080/13854040802681664
DO - 10.1080/13854040802681664
M3 - Article
C2 - 19370451
AN - SCOPUS:68949164878
SN - 1385-4046
VL - 23
SP - 944
EP - 961
JO - Clinical Neuropsychologist
JF - Clinical Neuropsychologist
IS - 6
ER -