Leukoaraiosis severity and list-learning in dementia

Catherine C. Price, Kelly Davis Garrett, Angela L. Jefferson, Stephanie Cosentino, Jared J. Tanner, Dana L. Penney, Rodney Swenson, Tania Giovannetti, Brianne Magouirk Bettcher, David J. Libon

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39 Scopus citations


In patients with dementia, leukoaraiosis (LA) was hypothesized to result in differential patterns of impairment on a verbal serial list-learning test. Using a visual rating scale, 144 dementia patients with ischemic scores 4 were re-categorized as having mild (n = 73), moderate (n = 44), or severe LA (n = 27). Mild LA was predicted to be associated with an amnestic list-learning profile, while severe LA was predicted to be associated with a dysexecutive profile. List-learning performances were standardized to a group of healthy older adults (n = 24). Analyses were conducted on a set of four factors derived from the list-learning paradigm, as well as error scores. Data indicate that LA severity is an important marker for understanding list learning in dementia.

Original languageEnglish (US)
Pages (from-to)944-961
Number of pages18
JournalClinical Neuropsychologist
Issue number6
StatePublished - Aug 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology
  • Clinical Psychology
  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health


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