Leukoaraiosis severity and list-learning in dementia

Catherine C. Price, Kelly Davis Garrett, Angela L. Jefferson, Stephanie Cosentino, Jared J. Tanner, Dana L. Penney, Rodney Swenson, Tania Giovannetti, Brianne Magouirk Bettcher, David J. Libon

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

In patients with dementia, leukoaraiosis (LA) was hypothesized to result in differential patterns of impairment on a verbal serial list-learning test. Using a visual rating scale, 144 dementia patients with ischemic scores 4 were re-categorized as having mild (n = 73), moderate (n = 44), or severe LA (n = 27). Mild LA was predicted to be associated with an amnestic list-learning profile, while severe LA was predicted to be associated with a dysexecutive profile. List-learning performances were standardized to a group of healthy older adults (n = 24). Analyses were conducted on a set of four factors derived from the list-learning paradigm, as well as error scores. Data indicate that LA severity is an important marker for understanding list learning in dementia.

Original languageEnglish (US)
Pages (from-to)944-961
Number of pages18
JournalClinical Neuropsychologist
Volume23
Issue number6
DOIs
StatePublished - Aug 2009

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology
  • Clinical Psychology
  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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