Elucidation of the metabolic pathways and controlling mechanisms in normal pulmonary tissue may be important not only in understanding but also in treating such disorders as pulmonary neoplasia, emphysema, and various infectious disease states. Utilizing in vitro techniques with rat lung slices, the authors confirmed that the lung, the organ with the greatest access to oxygen, produces primarily lactate from glucose. This apparent anaerobiosis may be a physiological means of ensuring maximal transport of oxygen across the alveolar capillary membrane and of protecting the integrity of the membrane during periods of hypoxia.
All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine
- Cardiology and Cardiovascular Medicine