Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy

Falk W. Lohoff, Thomas N. Ferraro, John P. Dahl, Marie A. Hildebrandt, Theresa M. Scattergood, Michael J. O'Connor, Michael R. Sperling, Dennis J. Dlugos, Wade H. Berrettini, Russell J. Buono

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17 Scopus citations

Abstract

Recently, an association between the C240T polymorphism in the brain-derived neurotrophic factor (BDNF) gene and partial epilepsy was demonstrated in a Japanese population. In this study we attempted to replicate the initial finding in a patient-control population of European ancestry and in addition tested whether the functional Val66Met polymorphism is associated with temporal lobe epilepsy (TLE). Genotypes of 151 TLE patients and 189 controls did not differ significantly for either of the variations. Results suggest that neither of the studied polymorphisms are strong susceptibility factors for TLE in this sample of individuals of European ancestry.

Original languageEnglish (US)
Pages (from-to)59-62
Number of pages4
JournalEpilepsy Research
Volume66
Issue number1-3
DOIs
StatePublished - Aug 2005

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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