Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy

Falk W. Lohoff; Thomas N. Ferraro; John P. Dahl; Marie A. Hildebrandt; Theresa M. Scattergood; Michael J. O'Connor; Michael R. Sperling; Dennis J. Dlugos; Wade H. Berrettini; Russell J. Buono

doi:10.1016/j.eplepsyres.2005.06.005

Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy

Falk W. Lohoff, Thomas N. Ferraro, John P. Dahl, Marie A. Hildebrandt, Theresa M. Scattergood, Michael J. O'Connor, Michael R. Sperling, Dennis J. Dlugos, Wade H. Berrettini, Russell J. Buono

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18 Scopus citations

Abstract

Recently, an association between the C240T polymorphism in the brain-derived neurotrophic factor (BDNF) gene and partial epilepsy was demonstrated in a Japanese population. In this study we attempted to replicate the initial finding in a patient-control population of European ancestry and in addition tested whether the functional Val66Met polymorphism is associated with temporal lobe epilepsy (TLE). Genotypes of 151 TLE patients and 189 controls did not differ significantly for either of the variations. Results suggest that neither of the studied polymorphisms are strong susceptibility factors for TLE in this sample of individuals of European ancestry.

Original language	English (US)
Pages (from-to)	59-62
Number of pages	4
Journal	Epilepsy Research
Volume	66
Issue number	1-3
DOIs	https://doi.org/10.1016/j.eplepsyres.2005.06.005
State	Published - Aug 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology

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10.1016/j.eplepsyres.2005.06.005

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Lohoff, F. W., Ferraro, T. N., Dahl, J. P., Hildebrandt, M. A., Scattergood, T. M., O'Connor, M. J., Sperling, M. R., Dlugos, D. J., Berrettini, W. H., & Buono, R. J. (2005). Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy. Epilepsy Research, 66(1-3), 59-62. https://doi.org/10.1016/j.eplepsyres.2005.06.005

@article{485ea3809d0a41d5a8f1a2164176b3a7,

title = "Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy",

abstract = "Recently, an association between the C240T polymorphism in the brain-derived neurotrophic factor (BDNF) gene and partial epilepsy was demonstrated in a Japanese population. In this study we attempted to replicate the initial finding in a patient-control population of European ancestry and in addition tested whether the functional Val66Met polymorphism is associated with temporal lobe epilepsy (TLE). Genotypes of 151 TLE patients and 189 controls did not differ significantly for either of the variations. Results suggest that neither of the studied polymorphisms are strong susceptibility factors for TLE in this sample of individuals of European ancestry.",

author = "Lohoff, {Falk W.} and Ferraro, {Thomas N.} and Dahl, {John P.} and Hildebrandt, {Marie A.} and Scattergood, {Theresa M.} and O'Connor, {Michael J.} and Sperling, {Michael R.} and Dlugos, {Dennis J.} and Berrettini, {Wade H.} and Buono, {Russell J.}",

note = "Funding Information: This work was supported by the Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania. Financial support is gratefully acknowledged from National Institutes of Health Grants R01 NS40396 (to R.J.B.) and R25 MH060490 (to F.W.L.).",

year = "2005",

month = aug,

doi = "10.1016/j.eplepsyres.2005.06.005",

language = "English (US)",

volume = "66",

pages = "59--62",

journal = "Epilepsy Research",

issn = "0920-1211",

publisher = "Elsevier B.V.",

number = "1-3",

}

TY - JOUR

T1 - Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy

AU - Lohoff, Falk W.

AU - Ferraro, Thomas N.

AU - Dahl, John P.

AU - Hildebrandt, Marie A.

AU - Scattergood, Theresa M.

AU - O'Connor, Michael J.

AU - Sperling, Michael R.

AU - Dlugos, Dennis J.

AU - Berrettini, Wade H.

AU - Buono, Russell J.

N1 - Funding Information: This work was supported by the Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania. Financial support is gratefully acknowledged from National Institutes of Health Grants R01 NS40396 (to R.J.B.) and R25 MH060490 (to F.W.L.).

PY - 2005/8

Y1 - 2005/8

N2 - Recently, an association between the C240T polymorphism in the brain-derived neurotrophic factor (BDNF) gene and partial epilepsy was demonstrated in a Japanese population. In this study we attempted to replicate the initial finding in a patient-control population of European ancestry and in addition tested whether the functional Val66Met polymorphism is associated with temporal lobe epilepsy (TLE). Genotypes of 151 TLE patients and 189 controls did not differ significantly for either of the variations. Results suggest that neither of the studied polymorphisms are strong susceptibility factors for TLE in this sample of individuals of European ancestry.

AB - Recently, an association between the C240T polymorphism in the brain-derived neurotrophic factor (BDNF) gene and partial epilepsy was demonstrated in a Japanese population. In this study we attempted to replicate the initial finding in a patient-control population of European ancestry and in addition tested whether the functional Val66Met polymorphism is associated with temporal lobe epilepsy (TLE). Genotypes of 151 TLE patients and 189 controls did not differ significantly for either of the variations. Results suggest that neither of the studied polymorphisms are strong susceptibility factors for TLE in this sample of individuals of European ancestry.

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DO - 10.1016/j.eplepsyres.2005.06.005

M3 - Article

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AN - SCOPUS:25844456860

SN - 0920-1211

VL - 66

SP - 59

EP - 62

JO - Epilepsy Research

JF - Epilepsy Research

IS - 1-3

ER -

Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy

Abstract

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