Lack of association between an interleukin 1 beta (IL-1β gene variation and refractory temporal lobe epilepsy

Russell J. Buono; Thomas N. Ferraro; Michael J. O'Connor; Michael R. Sperling; Stephen G. Ryan; Theresa Scattergood; Nicole Mulholland; Joan Gilmore; Falk W. Lohoff; Wade H. Berrettini

doi:10.1046/j.1528-1157.2001.42900.x

Lack of association between an interleukin 1 beta (IL-1β gene variation and refractory temporal lobe epilepsy

Russell J. Buono, Thomas N. Ferraro, Michael J. O'Connor, Michael R. Sperling, Stephen G. Ryan, Theresa Scattergood, Nicole Mulholland, Joan Gilmore, Falk W. Lohoff, Wade H. Berrettini

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Purpose: We attempted to confirm recent findings of Kanemoto et al. that demonstrated a positive association (p < 0.017) between a polymorphism in the promoter region of the interleukin 1-β (IL- 1β) gene and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS). Methods: We determined the frequency of this polymorphism in a group of 61 TLE+HS patients of European ancestry and compared it with that found in 119 ethnically matched control subjects. Results: Analysis of genotype and allele frequencies showed no statistically significant difference in the distribution of the polymorphism between the two groups (p = 0.10). Conclusions: These data suggest that this IL-1β promoter polymorphism does not act as a strong susceptibility factor for TLE+HS in a population of individuals of European ancestry.

Original language	English (US)
Pages (from-to)	782-784
Number of pages	3
Journal	Epilepsia
Volume	42
Issue number	6
DOIs	https://doi.org/10.1046/j.1528-1157.2001.42900.x
State	Published - 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology

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10.1046/j.1528-1157.2001.42900.x

Cite this

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title = "Lack of association between an interleukin 1 beta (IL-1β gene variation and refractory temporal lobe epilepsy",

abstract = "Purpose: We attempted to confirm recent findings of Kanemoto et al. that demonstrated a positive association (p < 0.017) between a polymorphism in the promoter region of the interleukin 1-β (IL- 1β) gene and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS). Methods: We determined the frequency of this polymorphism in a group of 61 TLE+HS patients of European ancestry and compared it with that found in 119 ethnically matched control subjects. Results: Analysis of genotype and allele frequencies showed no statistically significant difference in the distribution of the polymorphism between the two groups (p = 0.10). Conclusions: These data suggest that this IL-1β promoter polymorphism does not act as a strong susceptibility factor for TLE+HS in a population of individuals of European ancestry.",

author = "Buono, {Russell J.} and Ferraro, {Thomas N.} and O'Connor, {Michael J.} and Sperling, {Michael R.} and Ryan, {Stephen G.} and Theresa Scattergood and Nicole Mulholland and Joan Gilmore and Lohoff, {Falk W.} and Berrettini, {Wade H.}",

year = "2001",

doi = "10.1046/j.1528-1157.2001.42900.x",

language = "English (US)",

volume = "42",

pages = "782--784",

journal = "Epilepsia",

issn = "0013-9580",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "6",

}

TY - JOUR

T1 - Lack of association between an interleukin 1 beta (IL-1β gene variation and refractory temporal lobe epilepsy

AU - Buono, Russell J.

AU - Ferraro, Thomas N.

AU - O'Connor, Michael J.

AU - Sperling, Michael R.

AU - Ryan, Stephen G.

AU - Scattergood, Theresa

AU - Mulholland, Nicole

AU - Gilmore, Joan

AU - Lohoff, Falk W.

AU - Berrettini, Wade H.

PY - 2001

Y1 - 2001

N2 - Purpose: We attempted to confirm recent findings of Kanemoto et al. that demonstrated a positive association (p < 0.017) between a polymorphism in the promoter region of the interleukin 1-β (IL- 1β) gene and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS). Methods: We determined the frequency of this polymorphism in a group of 61 TLE+HS patients of European ancestry and compared it with that found in 119 ethnically matched control subjects. Results: Analysis of genotype and allele frequencies showed no statistically significant difference in the distribution of the polymorphism between the two groups (p = 0.10). Conclusions: These data suggest that this IL-1β promoter polymorphism does not act as a strong susceptibility factor for TLE+HS in a population of individuals of European ancestry.

AB - Purpose: We attempted to confirm recent findings of Kanemoto et al. that demonstrated a positive association (p < 0.017) between a polymorphism in the promoter region of the interleukin 1-β (IL- 1β) gene and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS). Methods: We determined the frequency of this polymorphism in a group of 61 TLE+HS patients of European ancestry and compared it with that found in 119 ethnically matched control subjects. Results: Analysis of genotype and allele frequencies showed no statistically significant difference in the distribution of the polymorphism between the two groups (p = 0.10). Conclusions: These data suggest that this IL-1β promoter polymorphism does not act as a strong susceptibility factor for TLE+HS in a population of individuals of European ancestry.

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JO - Epilepsia

JF - Epilepsia

IS - 6

ER -

Lack of association between an interleukin 1 beta (IL-1β gene variation and refractory temporal lobe epilepsy

Abstract

All Science Journal Classification (ASJC) codes

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