Lack of association between an interleukin 1 beta (IL-1β gene variation and refractory temporal lobe epilepsy

Russell J. Buono, Thomas N. Ferraro, Michael J. O'Connor, Michael R. Sperling, Stephen G. Ryan, Theresa Scattergood, Nicole Mulholland, Joan Gilmore, Falk W. Lohoff, Wade H. Berrettini

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Abstract

Purpose: We attempted to confirm recent findings of Kanemoto et al. that demonstrated a positive association (p < 0.017) between a polymorphism in the promoter region of the interleukin 1-β (IL- 1β) gene and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS). Methods: We determined the frequency of this polymorphism in a group of 61 TLE+HS patients of European ancestry and compared it with that found in 119 ethnically matched control subjects. Results: Analysis of genotype and allele frequencies showed no statistically significant difference in the distribution of the polymorphism between the two groups (p = 0.10). Conclusions: These data suggest that this IL-1β promoter polymorphism does not act as a strong susceptibility factor for TLE+HS in a population of individuals of European ancestry.

Original languageEnglish (US)
Pages (from-to)782-784
Number of pages3
JournalEpilepsia
Volume42
Issue number6
DOIs
StatePublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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