IP3R function in cells of the immune system

Askar M. Akimzhanov, Darren Boehning

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Calcium ions regulate almost all cellular processes. Inositol 1,4,5-trisphosphate receptors (IP3Rs) are ubiquitous calcium channels which mediate calcium release primarily from endoplasmic reticulum stores. IP3Rs are activated by the soluble second messenger inositol 1,4,5-trisphosphate (IP3), which is produced in response to various stimuli by the action of phospholipase C enzymes. Very soon after the discovery that IP3 is a calcium mobilizing second messenger, it was found that T-cell receptor signaling is dependent upon IP3R activity. It is now known that cell signaling throughout the immune system is dependent upon IP3R-dependent calcium release for many critical processes, including cellular activation, proliferation, and death. This channel plays a critical role in orchestrating the immune response in health and disease and thus offers potential as a therapeutic target in immune-related disorders.

Original languageEnglish (US)
Pages (from-to)329-339
Number of pages11
JournalWiley Interdisciplinary Reviews: Membrane Transport and Signaling
Volume1
Issue number3
DOIs
StatePublished - May 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Cellular and Molecular Neuroscience

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