Calcium ions regulate almost all cellular processes. Inositol 1,4,5-trisphosphate receptors (IP3Rs) are ubiquitous calcium channels which mediate calcium release primarily from endoplasmic reticulum stores. IP3Rs are activated by the soluble second messenger inositol 1,4,5-trisphosphate (IP3), which is produced in response to various stimuli by the action of phospholipase C enzymes. Very soon after the discovery that IP3 is a calcium mobilizing second messenger, it was found that T-cell receptor signaling is dependent upon IP3R activity. It is now known that cell signaling throughout the immune system is dependent upon IP3R-dependent calcium release for many critical processes, including cellular activation, proliferation, and death. This channel plays a critical role in orchestrating the immune response in health and disease and thus offers potential as a therapeutic target in immune-related disorders.
|Original language||English (US)|
|Number of pages||11|
|Journal||Wiley Interdisciplinary Reviews: Membrane Transport and Signaling|
|State||Published - May 2012|
All Science Journal Classification (ASJC) codes
- Cellular and Molecular Neuroscience