Inositol 1,4,5-trisphosphate receptors as signal integrators

Randen L. Patterson, Darren Boehning, Solomon H. Snyder

Research output: Contribution to journalReview articlepeer-review

380 Scopus citations


The inositol 1,4,5 trisphosphate (IP3) receptor (IP 3R) is a Ca2+ release channel that responds to the second messenger IP3. Exquisite modulation of intracellular Ca2+ release via IP3Rs is achieved by the ability of IP3R to integrate signals from numerous small molecules and proteins including nucleotides, kinases, and phosphatases, as well as nonenzyme proteins. Because the ion conduction pore composes only ∼5% of the IP3R, the great bulk of this large protein contains recognition sites for these substances. Through these regulatory mechanisms, IP3R modulates diverse cellular functions, which include, but are not limited to, contraction/excitation, secretion, gene expression, and cellular growth. We review the unique properties of the IP3R that facilitate cell-type and stimulus-dependent control of function, with special emphasis on protein-binding partners.

Original languageEnglish (US)
Pages (from-to)437-465
Number of pages29
JournalAnnual Review of Biochemistry
StatePublished - 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry


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