Inhibitory effects of 6-O-acylated L-ascorbic acids possessing a straight- or branched-acyl chain on Epstein-Barr virus activation

Shinichi Uesato; Yutaka Kitagawa; Tomohiro Kaijima; Harukuni Tokuda; Masao Okuda; Xiao Yang Mou; Teruo Mukainaka; Hoyoku Nishino

doi:10.1016/S0304-3835(01)00444-X

Inhibitory effects of 6-O-acylated L-ascorbic acids possessing a straight- or branched-acyl chain on Epstein-Barr virus activation

Shinichi Uesato
, Yutaka Kitagawa
, Tomohiro Kaijima
, Harukuni Tokuda
, Masao Okuda
, Xiao Yang Mou
, Teruo Mukainaka
, Hoyoku Nishino

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

6-O-Acylated L-ascorbic acids possessing a straight- or branched-acyl chain of varying length from C₄ to C₁₈ have been synthesized and evaluated their anti-tumor promoting effects on the activation of the Epstein-Barr virus early antigen. The derivatives having a straight- or branched-acyl chain of C₆ to C₁₁ carbon atoms exhibited marked effects.

Original language	English (US)
Pages (from-to)	143-146
Number of pages	4
Journal	Cancer Letters
Volume	166
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(01)00444-X
State	Published - May 26 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Access to Document

10.1016/S0304-3835(01)00444-X

Cite this

@article{e33b1942a3ec405da2092c38b98d52a7,

title = "Inhibitory effects of 6-O-acylated L-ascorbic acids possessing a straight- or branched-acyl chain on Epstein-Barr virus activation",

abstract = "6-O-Acylated L-ascorbic acids possessing a straight- or branched-acyl chain of varying length from C4 to C18 have been synthesized and evaluated their anti-tumor promoting effects on the activation of the Epstein-Barr virus early antigen. The derivatives having a straight- or branched-acyl chain of C6 to C11 carbon atoms exhibited marked effects.",

author = "Shinichi Uesato and Yutaka Kitagawa and Tomohiro Kaijima and Harukuni Tokuda and Masao Okuda and Mou, \{Xiao Yang\} and Teruo Mukainaka and Hoyoku Nishino",

note = "Funding Information: This research was financially supported by the Ministry of Education, Science, Sports and Culture, and Ministry of Health and Welfare, Japan. We thanks Ms Masako Akaji (Super-conducting NMR Spectrometer Laboratory, Faculty of Pharmaceutical Sciences, Kyoto University) for measurements of NMR spectra. We are also thankful to Dr Masanori Morita (Research Institute for Technology and Science, Kinki University) for measurements of MS spectra.",

year = "2001",

month = may,

day = "26",

doi = "10.1016/S0304-3835(01)00444-X",

language = "English (US)",

volume = "166",

pages = "143--146",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Inhibitory effects of 6-O-acylated L-ascorbic acids possessing a straight- or branched-acyl chain on Epstein-Barr virus activation

AU - Uesato, Shinichi

AU - Kitagawa, Yutaka

AU - Kaijima, Tomohiro

AU - Tokuda, Harukuni

AU - Okuda, Masao

AU - Mou, Xiao Yang

AU - Mukainaka, Teruo

AU - Nishino, Hoyoku

N1 - Funding Information: This research was financially supported by the Ministry of Education, Science, Sports and Culture, and Ministry of Health and Welfare, Japan. We thanks Ms Masako Akaji (Super-conducting NMR Spectrometer Laboratory, Faculty of Pharmaceutical Sciences, Kyoto University) for measurements of NMR spectra. We are also thankful to Dr Masanori Morita (Research Institute for Technology and Science, Kinki University) for measurements of MS spectra.

PY - 2001/5/26

Y1 - 2001/5/26

N2 - 6-O-Acylated L-ascorbic acids possessing a straight- or branched-acyl chain of varying length from C4 to C18 have been synthesized and evaluated their anti-tumor promoting effects on the activation of the Epstein-Barr virus early antigen. The derivatives having a straight- or branched-acyl chain of C6 to C11 carbon atoms exhibited marked effects.

AB - 6-O-Acylated L-ascorbic acids possessing a straight- or branched-acyl chain of varying length from C4 to C18 have been synthesized and evaluated their anti-tumor promoting effects on the activation of the Epstein-Barr virus early antigen. The derivatives having a straight- or branched-acyl chain of C6 to C11 carbon atoms exhibited marked effects.

UR - https://www.scopus.com/pages/publications/0035954130

UR - https://www.scopus.com/pages/publications/0035954130#tab=citedBy

U2 - 10.1016/S0304-3835(01)00444-X

DO - 10.1016/S0304-3835(01)00444-X

M3 - Article

C2 - 11311486

AN - SCOPUS:0035954130

SN - 0304-3835

VL - 166

SP - 143

EP - 146

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Inhibitory effects of 6-O-acylated L-ascorbic acids possessing a straight- or branched-acyl chain on Epstein-Barr virus activation

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this