Inhibitory effect of flavonoids from Citrus plants on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors

Yukiko Iwase, Yuko Takemura, Motoharu Ju-Ichi, Chihiro Ito, Hiroshi Furukawa, Satoru Kawaii, Masamichi Yano, Xiao Yang Mou, Junko Takayasu, Harukuni Tokuda, Hoyoku Nishino

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

To search for possible anti-tumor promoters, thirteen flavones (1-13) obtained from the peel of Citrus plants were examined for their inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation by a short-term in vitro assay. Of these flavones, 3,5,6,7,8,3',4'-heptamethoxyflavone (HPT) (13) exhibited significant inhibitory effects on the EBV-EA activation induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA). Further, compound 13 exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)101-105
Number of pages5
JournalCancer Letters
Volume154
Issue number1
DOIs
StatePublished - Jun 1 2000

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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