Inhibition of pseudomonas aeruginosa biofilm formation with surface modified polymeric nanoparticles

Tyler R. Flockton, Logan Schnorbus, Agustin Araujo, Jill Adams, Maryjane Hammel, Lark J. Perez

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The gram-negative bacterial pathogen Pseudomonas aeruginosa represents a prominent clinical concern. Due to the observed high levels of antibiotic resistance, copious biofilm formation, and wide array of virulence factors produced by these bacteria, new treatment technologies are required. Here, we present the development of a series of P. aeruginosa LecA-targeted polymeric nanoparticles and demonstrate the anti-adhesion and biofilm inhibitory properties of these constructs.

Original languageEnglish (US)
Article number55
JournalPathogens
Volume8
Issue number2
DOIs
StatePublished - Jun 2019

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Molecular Biology
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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