Inadequate sleep is a risk factor for pediatric hypertension: the pathophysiologic and socioeconomic correlates

Abstract: The increasing prevalence of pediatric hypertension is concerning to our population because cardiovascular diseases are a leading cause of death in adults. Studies have shown that sleep disturbances in children, such as sleep fragmentation, increase blood pressure and lead to adult hypertension. However, the mechanisms by which this occurs are not fully understood. Most studies regarding sleep disturbances and hypertension are within adults, leaving the adolescent population understudied. In this review, we will describe the physiology of sleep, compare blood pressure variations between adults and adolescents, and discuss social issues regarding sleep fragmentation in children. In addition, we will also discuss the limitations of the studies available and what future research needs to be conducted. Impact: Pediatric hypertension is a complex condition that has various underlying causes, thus making treatments complicated. We describe the physiology of sleep, compare blood pressure variations between adults and adolescents, and discuss social issues regarding sleep fragmentation in children. We synthesize and connect studies to enhance knowledge of the issues that lead to the development of hypertension in pediatrics. We show the limitations of previous studies and describe future research that can further our understanding in the development of pediatric hypertension.