In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa

Gustavo Moura-Letts; Leon F. Villegas; Ana Marçalo; Abraham J. Vaisberg; Gerald B. Hammond

doi:10.1021/np0601152

In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa

Gustavo Moura-Letts, Leon F. Villegas, Ana Marçalo, Abraham J. Vaisberg, Gerald B. Hammond

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9% (p < 0.01) above the control. The highest cicatrizant activity in mice was obtained by applying 40 μg of oleanolic acid per gram of body weight.

Original language	English (US)
Pages (from-to)	978-979
Number of pages	2
Journal	Journal of Natural Products
Volume	69
Issue number	6
DOIs	https://doi.org/10.1021/np0601152
State	Published - Jun 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np0601152

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abstract = "Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9% (p < 0.01) above the control. The highest cicatrizant activity in mice was obtained by applying 40 μg of oleanolic acid per gram of body weight.",

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AU - Marçalo, Ana

AU - Vaisberg, Abraham J.

AU - Hammond, Gerald B.

PY - 2006/6

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In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa

Abstract

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