In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa

Gustavo Moura-Letts, Leon F. Villegas, Ana Marçalo, Abraham J. Vaisberg, Gerald B. Hammond

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9% (p < 0.01) above the control. The highest cicatrizant activity in mice was obtained by applying 40 μg of oleanolic acid per gram of body weight.

Original languageEnglish (US)
Pages (from-to)978-979
Number of pages2
JournalJournal of Natural Products
Volume69
Issue number6
DOIs
StatePublished - Jun 2006

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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