In vitro biodegradation behavior, mechanical properties, and cytotoxicity of biodegradable Zn-Mg alloy

Haibo Gong, Kun Wang, Randy Strich, Jack G. Zhou

Research output: Contribution to journalArticlepeer-review

194 Scopus citations

Abstract

Zinc-Magnesium (Zn-Mg) alloy as a novel biodegradable metal holds great potential in biodegradable implant applications as it is more corrosion resistant than Magnesium (Mg). However, the mechanical properties, biodegradation uniformity, and cytotoxicity of Zn-Mg alloy remained as concerns. In this study, hot extrusion process was applied to Zn-1 wt % Mg (Zn-1Mg) to refine its microstructure. Effects of hot extrusion on biodegradation behavior and mechanical properties of Zn-1Mg were investigated in comparison with Mg rare earth element alloy WE43. Metallurgical analysis revealed significant grain size reduction, and immersion test found that corrosion rates of WE43 and Zn-1Mg were reduced by 35% and 57%, respectively after extrusion. Moreover, hot extrusion resulted in a much more uniform biodegradation in extruded Zn-1Mg alloy and WE43. In vitro cytotoxicity test results indicated that Zn-1Mg alloy was biocompatible. Therefore, hot extruded Zn-1Mg with homogenous microstructure, uniform as well as slow degradation, improved mechanical properties, and good biocompatibility was believed to be an excellent candidate material for load-bearing biodegradable implant application.

Original languageEnglish (US)
Pages (from-to)1632-1640
Number of pages9
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume103
Issue number8
DOIs
StatePublished - Nov 2015

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

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