Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts

Julie L. Eiseman; Lihua Bai; Won Hyuk Jung; Gustavo Moura-Letts; Billy W. Day; Dennis P. Curran

doi:10.1021/jm800979v

Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts

Julie L. Eiseman, Lihua Bai, Won Hyuk Jung, Gustavo Moura-Letts, Billy W. Day, Dennis P. Curran

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Structure-activity studies centered on the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogues. From these compounds, 6-epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthesis that produced more than 30 mg of 6-epi-dictyostatin. The compound was found to have potent antitumor activity in SCID mice bearing MDA-MB231 human breast cancer xenografts.

Original language	English (US)
Pages (from-to)	6650-6653
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	51
Issue number	21
DOIs	https://doi.org/10.1021/jm800979v
State	Published - Nov 13 2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery

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10.1021/jm800979v

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title = "Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts",

abstract = "Structure-activity studies centered on the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogues. From these compounds, 6-epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthesis that produced more than 30 mg of 6-epi-dictyostatin. The compound was found to have potent antitumor activity in SCID mice bearing MDA-MB231 human breast cancer xenografts.",

author = "Eiseman, {Julie L.} and Lihua Bai and Jung, {Won Hyuk} and Gustavo Moura-Letts and Day, {Billy W.} and Curran, {Dennis P.}",

year = "2008",

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language = "English (US)",

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T1 - Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts

AU - Eiseman, Julie L.

AU - Bai, Lihua

AU - Jung, Won Hyuk

AU - Moura-Letts, Gustavo

AU - Day, Billy W.

AU - Curran, Dennis P.

PY - 2008/11/13

Y1 - 2008/11/13

N2 - Structure-activity studies centered on the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogues. From these compounds, 6-epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthesis that produced more than 30 mg of 6-epi-dictyostatin. The compound was found to have potent antitumor activity in SCID mice bearing MDA-MB231 human breast cancer xenografts.

AB - Structure-activity studies centered on the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogues. From these compounds, 6-epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthesis that produced more than 30 mg of 6-epi-dictyostatin. The compound was found to have potent antitumor activity in SCID mice bearing MDA-MB231 human breast cancer xenografts.

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JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 21

ER -

Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts

Abstract

All Science Journal Classification (ASJC) codes

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