Structure-activity studies centered on the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogues. From these compounds, 6-epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthesis that produced more than 30 mg of 6-epi-dictyostatin. The compound was found to have potent antitumor activity in SCID mice bearing MDA-MB231 human breast cancer xenografts.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Medicinal Chemistry|
|State||Published - Nov 13 2008|
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Drug Discovery