Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: A patient-level quantitative review of randomized trials

David R. Andes, Nasia Safdar, John W. Baddley, Geoffrey Playford, Annette C. Reboli, John H. Rex, Jack D. Sobel, Peter G. Pappas, Bart Jan Kullberg

    Research output: Contribution to journalReview articlepeer-review

    489 Scopus citations

    Abstract

    Background. Invasive candidiasis (IC) is an important healthcare-related infection, with increasing incidence and a crude mortality exceeding 50%. Numerous treatment options are available yet comparative studies have not identified optimal therapy.Methods.We conducted an individual patient-level quantitative review of randomized trials for treatment of IC and to assess the impact of host-, organism-, and treatment-related factors on mortality and clinical cure. Studies were identified by searching computerized databases and queries of experts in the field for randomized trials comparing the effect of ≥2 antifungals for treatment of IC. Univariate and multivariable analyses were performed to determine factors associated with patient outcomes. Results. Data from 1915 patients were obtained from 7 trials. Overall mortality among patients in the entire data set was 31.4%, and the rate of treatment success was 67.4%. Logistic regression analysis for the aggregate data set identified increasing age (odds ratio [OR], 1.01; 95% confidence interval [CI], 1.00-1.02; P =. 02), the Acute Physiology and Chronic Health Evaluation II score (OR, 1.11; 95% CI, 1.08-1.14; P =. 0001), use of immunosuppressive therapy (OR, 1.69; 95% CI, 1.18-2.44; P =. 001), and infection with Candida tropicalis (OR, 1.64; 95% CI, 1.11-2.39; P =. 01) as predictors of mortality. Conversely, removal of a central venous catheter (CVC) (OR, 0.50; 95% CI,. 35-.72; P =. 0001) and treatment with an echinocandin antifungal (OR, 0.65; 95% CI,. 45-.94; P =. 02) were associated with decreased mortality. Similar findings were observed for the clinical success end point. Conclusions. Two treatment-related factors were associated with improved survival and greater clinical success: use of an echinocandin and removal of the CVC.

    Original languageEnglish (US)
    Pages (from-to)1110-1122
    Number of pages13
    JournalClinical Infectious Diseases
    Volume54
    Issue number8
    DOIs
    StatePublished - Apr 15 2012

    All Science Journal Classification (ASJC) codes

    • Microbiology (medical)
    • Infectious Diseases

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