Abstract
Aging is a complicated process characterized by a progressive loss of homeostasis, which results in an increased vulnerability to multiple diseases. HIV-1-infected patients demonstrate a premature aging phenotype and develop certain age-related diseases earlier in their lifespan than what is seen in the general population. Age-related comorbidities may include the development of bone disease, metabolic disorders, neurologic impairment and immunosenescence. Age also appears to have an effect on traditional markers of HIV-1 disease progression, including CD4+ T-cell count and viral load. These effects are not only a consequence of HIV-1 infection, but in many cases, are also linked to antiretroviral therapy. This review summarizes the complex interplay between HIV-1 infection and aging, and the impact that aging has on markers of HIV-1 disease.
Original language | English (US) |
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Pages (from-to) | 81-101 |
Number of pages | 21 |
Journal | Future Virology |
Volume | 8 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2013 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Virology