Impact of age on markers of HIV-1 disease

Vanessa Pirrone, David J. Libon, Christian Sell, Chad A. Lerner, Michael R. Nonnemacher, Brian Wigdahl

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Aging is a complicated process characterized by a progressive loss of homeostasis, which results in an increased vulnerability to multiple diseases. HIV-1-infected patients demonstrate a premature aging phenotype and develop certain age-related diseases earlier in their lifespan than what is seen in the general population. Age-related comorbidities may include the development of bone disease, metabolic disorders, neurologic impairment and immunosenescence. Age also appears to have an effect on traditional markers of HIV-1 disease progression, including CD4+ T-cell count and viral load. These effects are not only a consequence of HIV-1 infection, but in many cases, are also linked to antiretroviral therapy. This review summarizes the complex interplay between HIV-1 infection and aging, and the impact that aging has on markers of HIV-1 disease.

Original languageEnglish (US)
Pages (from-to)81-101
Number of pages21
JournalFuture Virology
Volume8
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Virology

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