Impact and pathogenesis of osteoporosis

Research output: Contribution to journalReview articlepeer-review


Osteoporosis is a major health problem. It is a skeletal disorder characterized by low bone mass and increased susceptibility to fractures. In the United States, osteoporosis accounts for 1.5 million fractures annually. Forty percent of Caucasian women will experience an osteoporotic fracture during their lifetime. The consequences of osteoporosis include decreased functional independence and increased morbidity and mortality. Osteoporosis is a multi-factorial disease. It can result pathogenetically from inadequate peak bone mass, excessive bone resorption or impaired bone formation, and be influenced by genetic, hormonal, and environmental factors. The relative importance of these factors may differ among patients and is not fully understood. Nevertheless, improved understanding of specific pathogenetic mechanisms is critical in developing an optimal approach to diagnosis, prevention, and treatment of this devastating disease.

Original languageEnglish (US)
Pages (from-to)27-33
Number of pages7
JournalAnnals of Long-Term Care
Issue number3
StatePublished - Mar 1 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Gerontology
  • Geriatrics and Gerontology


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