Image Guidance in External Beam Accelerated Partial Breast Irradiation: Comparison of Surrogates for the Lumpectomy Cavity

Purpose: To compare localization of the lumpectomy cavity by using breast surface matching vs. clips for image-guided external beam accelerated partial breast irradiation. Methods and Materials: Twenty-seven patients with breast cancer with two computed tomography (CT) scans each had three CT registrations performed: (1) to bony anatomy, (2) to the center of mass (COM) of surgical clips, and (3) to the breast surface. The cavity COM was defined in both the initial and second CT scans after each type of registration, and distances between COMs (ΔCOM_Bone, ΔCOM_Clips, and ΔCOM_Surface) were determined. Smaller ΔCOMs were interpreted as better localizations. Correlation coefficients were calculated for ΔCOM vs. several variables. Results: The ΔCOM_Bone (mean, 7 ± 2 [SD] mm) increased with breast volume (r = 0.4; p = 0.02) and distance from the chest wall (r = 0.5; p = 0.003). Relative to bony registration, clip registration provided better localization (ΔCOM_Clips < ΔCOM_Bone) in 25 of 27 cases. Breast surface matching improved cavity localization (ΔCOM_Surface < ΔCOM_Bone) in 19 of 27 cases. Mean improvements (ΔCOM_Bone - ΔCOM_{Clips or Surface}) were 4 ± 3 and 2 ± 4 mm, respectively. In terms of percentage of improvement ([ΔCOM_Bone - ΔCOM_{Clips or Surface}]/ΔCOM_Bone), only surface matching showed a correlation with breast volume. Clip localization outperformed surface registration for cavities located superior to the breast COM. Conclusions: Use of either breast surface or surgical clips as surrogates for the cavity results in improved localization in most patients compared with bony registration and may allow smaller planning target volume margins for external beam accelerated partial breast irradiation. Compared with surface registration, clip registration may be less sensitive to anatomic characteristics and therefore more broadly applicable.