Higher education institutions around the world have increasingly come to see information and communication technology (ICT) as vital to the business of teaching and learning. Institutions invest a considerable amount of time and resources to erecting the appropriate institutional infrastructure, creating policy and practice, instituting strategy, training faculty, and building the capacity of technology staff. However, in under-resourced regions of the world, such as Africa, ICT, the availability and use of, has several challenges to overcome: a lack of institutional infrastructure, sufficient bandwidth, and limited capacity to employ ICT in the research process or the classroom. Universities report inadequate funding, poor management and infrastructure, resistance to change, inadequate training, and high costs associated with effective ICT use. Moreover, critiques of Western technopositivism surface misgivings related to the performance outcomes and appropriateness of ICT adoption in Africa. In this chapter, the author will explore the work of international organizations and regional and national research and education networks in the diffusion of ICT discourse, consider on-the-ground adoptions and innovation at universities in Nigeria, and reflect on the suitability and sustainability of technology adoption, all within an ICT for development (ICT4D) framework that lenses the evolution of technological applications in higher education. This chapter is significant in that it connects African higher education to ICT4D and frames the various discourses, policy landscapes and practice arenas, as they relate to international actors, continental initiatives, networks, universities, and faculty.