Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for 29Si Magnetic Resonance Imaging

Hyeonglim Seo, Ikjang Choi, Nicholas Whiting, Jingzhe Hu, Quy Son Luu, Shivanand Pudakalakatti, Caitlin McCowan, Yaewon Kim, Niki Zacharias, Seunghyun Lee, Pratip Bhattacharya, Youngbok Lee

    Research output: Contribution to journalArticlepeer-review

    7 Scopus citations

    Abstract

    Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for 29Si magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their 29Si MR signals; the particles demonstrated long 29Si spin-lattice relaxation (T1) times (∼25 mins), which suggests potential applicability for medical imaging. Furthermore, 29Si hyperpolarization levels were sufficient to allow 29Si MRI in phantoms. These results underscore the potential of porous silicon nanoparticles that, when combined with hyperpolarized magnetic resonance imaging, can be a powerful theragnostic deep tissue imaging platform to interrogate various biomolecular processes in vivo.

    Original languageEnglish (US)
    Pages (from-to)2143-2147
    Number of pages5
    JournalChemPhysChem
    Volume19
    Issue number17
    DOIs
    StatePublished - Sep 5 2018

    All Science Journal Classification (ASJC) codes

    • Atomic and Molecular Physics, and Optics
    • Physical and Theoretical Chemistry

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