Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse

Wade H. Berrettini, Margret R. Hoehe, Thomas N. Ferraro, Peter A. DeMaria, Edward Gottheil

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


Two polymorphisms of the human mu opioid receptor gene are described. A non-coding region polymorphism (G to T) occurs at nucleotide 175 preceding the initiation of translation. A coding polymorphism in exon 1 (C to T) at nucleotide 229 changes an alanine residue to a valine residue. Frequencies of these polymorphisms were examined in groups of cocaine and/or opioid dependent individuals and matched controls. There were no significant differences between groups, although a trend (p = 0.05) towards a higher frequency of the 229 valine allele was observed in the substance abuse group, suggesting a need for large, well-controlled studies of this polymorphism in severe substance abusers.

Original languageEnglish (US)
Pages (from-to)303-308
Number of pages6
JournalAddiction Biology
Issue number3
StatePublished - 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Medicine (miscellaneous)
  • Pharmacology


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