Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae

Lark J. Perez; Theodora K. Karagounis; Amanda Hurley; Bonnie L. Bassler; Martin F. Semmelhack

doi:10.1039/c3sc52572d

Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae

Lark J. Perez, Theodora K. Karagounis, Amanda Hurley, Bonnie L. Bassler, Martin F. Semmelhack

Chemistry

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17 Scopus citations

Abstract

In the Vibrio cholerae pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of V. cholerae quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in V. cholerae.

Original language	English (US)
Pages (from-to)	151-155
Number of pages	5
Journal	Chemical Science
Volume	5
Issue number	1
DOIs	https://doi.org/10.1039/c3sc52572d
State	Published - Jan 2014

All Science Journal Classification (ASJC) codes

General Chemistry

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10.1039/c3sc52572d

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title = "Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae",

abstract = "In the Vibrio cholerae pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of V. cholerae quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in V. cholerae.",

author = "Perez, {Lark J.} and Karagounis, {Theodora K.} and Amanda Hurley and Bassler, {Bonnie L.} and Semmelhack, {Martin F.}",

year = "2014",

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AU - Perez, Lark J.

AU - Karagounis, Theodora K.

AU - Hurley, Amanda

AU - Bassler, Bonnie L.

AU - Semmelhack, Martin F.

PY - 2014/1

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N2 - In the Vibrio cholerae pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of V. cholerae quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in V. cholerae.

AB - In the Vibrio cholerae pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of V. cholerae quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in V. cholerae.

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Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae

Abstract

All Science Journal Classification (ASJC) codes

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