High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments

Jason G. Skinner, Kaili Ranta, Nicholas Whiting, Aaron M. Coffey, Panayiotis Nikolaou, Matthew S. Rosen, Eduard Y. Chekmenev, Peter G. Morris, Michael J. Barlow, Boyd M. Goodson

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Spin-exchange optical pumping (SEOP) can enhance the NMR sensitivity of noble gases by up to five orders of magnitude at Tesla-strength magnetic fields. SEOP-generated hyperpolarised (HP) 129Xe is a promising contrast agent for lung imaging but an ongoing barrier to widespread clinical usage has been economical production of sufficient quantities with high 129Xe polarisation. Here, the ‘standard model’ of SEOP, which was previously used in the optimisation of continuous-flow 129Xe polarisers, is modified for validation against two Xe-rich stopped-flow SEOP datasets. We use this model to examine ways to increase HP Xe production efficiency in stopped-flow 129Xe polarisers and provide further insight into the underlying physics of Xe-rich stopped-flow SEOP at high laser fluxes.

Original languageEnglish (US)
Article number106686
JournalJournal of Magnetic Resonance
Volume312
DOIs
StatePublished - Mar 2020

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics

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    Skinner, J. G., Ranta, K., Whiting, N., Coffey, A. M., Nikolaou, P., Rosen, M. S., Chekmenev, E. Y., Morris, P. G., Barlow, M. J., & Goodson, B. M. (2020). High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments. Journal of Magnetic Resonance, 312, [106686]. https://doi.org/10.1016/j.jmr.2020.106686