Hepatic fat accumulation in man with excess parenteral glucose

T. Peter Stein; James L. Mullen

doi:10.1016/S0271-5317(85)80045-2

Hepatic fat accumulation in man with excess parenteral glucose

T. Peter Stein, James L. Mullen

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Abstract

The threshold for the conversion of parenterally administered glucose to hepatic fat was estimated by measuring the amount of fat accumulated in the liver of malnourished cancer patients. Patients were given 7-10 days of TPN with glucose (47 kcal/kg/d) as the sole non-protein calorie source. The derived threshold, 42 kcal/kd/day) is in reasonable accord with the value for the glucose oxidation capacity derived from indirect methods. Most of the newly synthesized fat accumulates in the liver.

Original language	English (US)
Pages (from-to)	1347-1351
Number of pages	5
Journal	Nutrition Research
Volume	5
Issue number	12
DOIs	https://doi.org/10.1016/S0271-5317(85)80045-2
State	Published - Dec 1985

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Endocrinology
Nutrition and Dietetics

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title = "Hepatic fat accumulation in man with excess parenteral glucose",

abstract = "The threshold for the conversion of parenterally administered glucose to hepatic fat was estimated by measuring the amount of fat accumulated in the liver of malnourished cancer patients. Patients were given 7-10 days of TPN with glucose (47 kcal/kg/d) as the sole non-protein calorie source. The derived threshold, 42 kcal/kd/day) is in reasonable accord with the value for the glucose oxidation capacity derived from indirect methods. Most of the newly synthesized fat accumulates in the liver.",

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note = "Funding Information: Supported by USPHS grant #33415, VA Medical Research Service",

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AU - Mullen, James L.

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Y1 - 1985/12

N2 - The threshold for the conversion of parenterally administered glucose to hepatic fat was estimated by measuring the amount of fat accumulated in the liver of malnourished cancer patients. Patients were given 7-10 days of TPN with glucose (47 kcal/kg/d) as the sole non-protein calorie source. The derived threshold, 42 kcal/kd/day) is in reasonable accord with the value for the glucose oxidation capacity derived from indirect methods. Most of the newly synthesized fat accumulates in the liver.

AB - The threshold for the conversion of parenterally administered glucose to hepatic fat was estimated by measuring the amount of fat accumulated in the liver of malnourished cancer patients. Patients were given 7-10 days of TPN with glucose (47 kcal/kg/d) as the sole non-protein calorie source. The derived threshold, 42 kcal/kd/day) is in reasonable accord with the value for the glucose oxidation capacity derived from indirect methods. Most of the newly synthesized fat accumulates in the liver.

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