Heat transfer analysis of catheters used for localized tissue cooling to attenuate reperfusion injury

Thomas L. Merrill, Jennifer E. Mitchell, Denise R. Merrill

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Recent revascularization success for ischemic stroke patients using stentrievers has created a new opportunity for therapeutic hypothermia. By using short term localized tissue cooling interventional catheters can be used to reduce reperfusion injury and improve neurological outcomes. Using experimental testing and a well-established heat exchanger design approach, the ɛ-NTU method, this paper examines the cooling performance of commercially available catheters as function of four practical parameters: (1) infusion flow rate, (2) catheter location in the body, (3) catheter configuration and design, and (4) cooling approach. While saline batch cooling outperformed closed-loop autologous blood cooling at all equivalent flow rates in terms of lower delivered temperatures and cooling capacity, hemodilution, systemic and local, remains a concern. For clinicians and engineers this paper provides insights for the selection, design, and operation of commercially available catheters used for localized tissue cooling.

Original languageEnglish (US)
Pages (from-to)758-766
Number of pages9
JournalMedical Engineering and Physics
Volume38
Issue number8
DOIs
StatePublished - 2016

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomedical Engineering

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