Haem as a multifunctional regulator

G. Padmanaban; V. Venkateswar; P. N. Rangarajan

doi:10.1016/0968-0004(89)90182-5

Haem as a multifunctional regulator

G. Padmanaban, V. Venkateswar, P. N. Rangarajan

Cell Biology

Research output: Contribution to journal › Review article › peer-review

147 Scopus citations

Abstract

Haem has long been known as the prosthetic group of haemoproteins such as haemoglobin, catalase and the cytochromes. Its biosynthesis is regulated by feedback mechanisms that ensure its adequate production but prevent its overaccumulation, which is highly deleterious as diseases such as porphyrias attest. However, recent years have seen rapid strides in our understanding of how haem (or more accurately haemin, its oxidized form) itself acts as an intracellular regulator of a variety of other metabolic pathways for systems that utilize oxygen.

Original language	English (US)
Pages (from-to)	492-496
Number of pages	5
Journal	Trends in Biochemical Sciences
Volume	14
Issue number	12
DOIs	https://doi.org/10.1016/0968-0004(89)90182-5
State	Published - Dec 1989

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology

Access to Document

10.1016/0968-0004(89)90182-5

Fingerprint Dive into the research topics of 'Haem as a multifunctional regulator'. Together they form a unique fingerprint.

Cite this

@article{45f6495d1c8440c7a6cdcbba5c20d24d,

title = "Haem as a multifunctional regulator",

abstract = "Haem has long been known as the prosthetic group of haemoproteins such as haemoglobin, catalase and the cytochromes. Its biosynthesis is regulated by feedback mechanisms that ensure its adequate production but prevent its overaccumulation, which is highly deleterious as diseases such as porphyrias attest. However, recent years have seen rapid strides in our understanding of how haem (or more accurately haemin, its oxidized form) itself acts as an intracellular regulator of a variety of other metabolic pathways for systems that utilize oxygen.",

author = "G. Padmanaban and V. Venkateswar and Rangarajan, {P. N.}",

year = "1989",

month = dec,

doi = "10.1016/0968-0004(89)90182-5",

language = "English (US)",

volume = "14",

pages = "492--496",

journal = "Trends in Biochemical Sciences",

issn = "0376-5067",

publisher = "Elsevier Limited",

number = "12",

}

TY - JOUR

T1 - Haem as a multifunctional regulator

AU - Padmanaban, G.

AU - Venkateswar, V.

AU - Rangarajan, P. N.

PY - 1989/12

Y1 - 1989/12

N2 - Haem has long been known as the prosthetic group of haemoproteins such as haemoglobin, catalase and the cytochromes. Its biosynthesis is regulated by feedback mechanisms that ensure its adequate production but prevent its overaccumulation, which is highly deleterious as diseases such as porphyrias attest. However, recent years have seen rapid strides in our understanding of how haem (or more accurately haemin, its oxidized form) itself acts as an intracellular regulator of a variety of other metabolic pathways for systems that utilize oxygen.

AB - Haem has long been known as the prosthetic group of haemoproteins such as haemoglobin, catalase and the cytochromes. Its biosynthesis is regulated by feedback mechanisms that ensure its adequate production but prevent its overaccumulation, which is highly deleterious as diseases such as porphyrias attest. However, recent years have seen rapid strides in our understanding of how haem (or more accurately haemin, its oxidized form) itself acts as an intracellular regulator of a variety of other metabolic pathways for systems that utilize oxygen.

UR - http://www.scopus.com/inward/record.url?scp=0024330121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024330121&partnerID=8YFLogxK

U2 - 10.1016/0968-0004(89)90182-5

DO - 10.1016/0968-0004(89)90182-5

M3 - Review article

C2 - 2696180

AN - SCOPUS:0024330121

VL - 14

SP - 492

EP - 496

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0376-5067

IS - 12

ER -