Haem as a multifunctional regulator

G. Padmanaban, V. Venkateswar, P. N. Rangarajan

Research output: Contribution to journalReview articlepeer-review

162 Scopus citations


Haem has long been known as the prosthetic group of haemoproteins such as haemoglobin, catalase and the cytochromes. Its biosynthesis is regulated by feedback mechanisms that ensure its adequate production but prevent its overaccumulation, which is highly deleterious as diseases such as porphyrias attest. However, recent years have seen rapid strides in our understanding of how haem (or more accurately haemin, its oxidized form) itself acts as an intracellular regulator of a variety of other metabolic pathways for systems that utilize oxygen.

Original languageEnglish (US)
Pages (from-to)492-496
Number of pages5
JournalTrends in Biochemical Sciences
Issue number12
StatePublished - Dec 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


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