TY - JOUR
T1 - Haem as a multifunctional regulator
AU - Padmanaban, G.
AU - Venkateswar, V.
AU - Rangarajan, P. N.
PY - 1989/12
Y1 - 1989/12
N2 - Haem has long been known as the prosthetic group of haemoproteins such as haemoglobin, catalase and the cytochromes. Its biosynthesis is regulated by feedback mechanisms that ensure its adequate production but prevent its overaccumulation, which is highly deleterious as diseases such as porphyrias attest. However, recent years have seen rapid strides in our understanding of how haem (or more accurately haemin, its oxidized form) itself acts as an intracellular regulator of a variety of other metabolic pathways for systems that utilize oxygen.
AB - Haem has long been known as the prosthetic group of haemoproteins such as haemoglobin, catalase and the cytochromes. Its biosynthesis is regulated by feedback mechanisms that ensure its adequate production but prevent its overaccumulation, which is highly deleterious as diseases such as porphyrias attest. However, recent years have seen rapid strides in our understanding of how haem (or more accurately haemin, its oxidized form) itself acts as an intracellular regulator of a variety of other metabolic pathways for systems that utilize oxygen.
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U2 - 10.1016/0968-0004(89)90182-5
DO - 10.1016/0968-0004(89)90182-5
M3 - Review article
C2 - 2696180
AN - SCOPUS:0024330121
VL - 14
SP - 492
EP - 496
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
SN - 0376-5067
IS - 12
ER -