TY - JOUR
T1 - Green design alternatives for isopropanol recovery in the celecoxib process
AU - Slater, C. Stewart
AU - Savelski, Mariano
AU - Hounsell, Gregory
AU - Pilipauskas, Daniel
AU - Urbanski, Frank
N1 - Funding Information:
Acknowledgments The authors acknowledge the Rowan Engineering Clinic students: Anthony Furiato, Kyle Lynch and Timothy Moroz. The authors appreciate the guidance provided by Mr. Jorge Belgodere of the Pfizer Barceloneta plant. The authors thank the Pfizer Green Chemistry program and Pfizer Green Chemistry Lead, Dr. Peter Dunn for their support of the Rowan clinic partnership. The authors acknowledge the support of the U.S. Environmental Protection agency through the Pollution Prevention grant program (NP97257006-0) for their support of the Rowan projects with the green engineering in pharmaceutical manufacturing initiative.
PY - 2012/8
Y1 - 2012/8
N2 - Various approaches to solvent recovery have been studied for the manufacturing process of celecoxib, the active ingredient in Celebrex. A design case study has been performed by Rowan University with Pfizer through a green engineering partnership program. The manufacturing operation at one of their plants was evaluated and several green engineering alternatives for the purification and recovery of isopropanol (IPA) from waste streams proposed. This separation is complex due to the multiple waste streams generated, with varying compositions of IPA, ethanol, methanol, water, and dissolved solids. Overall goals were waste minimization and IPA recovery and purification. A conceptual study of distillation, extraction, reactive distillation, adsorption, and membrane-based processes was performed. Through use of computer simulation and literature/design methodologies, traditional methods were shown to be unable to obtain high IPA purities with the available equipment. Several green design approaches were evaluated using distillation combined with either molecular sieve adsorption or membrane pervaporation. These process schemes appear to have the most promise to effectively recover and purify IPA. The case study describes equipment and processing issues, and estimates environmental impacts from a life cycle analysis.
AB - Various approaches to solvent recovery have been studied for the manufacturing process of celecoxib, the active ingredient in Celebrex. A design case study has been performed by Rowan University with Pfizer through a green engineering partnership program. The manufacturing operation at one of their plants was evaluated and several green engineering alternatives for the purification and recovery of isopropanol (IPA) from waste streams proposed. This separation is complex due to the multiple waste streams generated, with varying compositions of IPA, ethanol, methanol, water, and dissolved solids. Overall goals were waste minimization and IPA recovery and purification. A conceptual study of distillation, extraction, reactive distillation, adsorption, and membrane-based processes was performed. Through use of computer simulation and literature/design methodologies, traditional methods were shown to be unable to obtain high IPA purities with the available equipment. Several green design approaches were evaluated using distillation combined with either molecular sieve adsorption or membrane pervaporation. These process schemes appear to have the most promise to effectively recover and purify IPA. The case study describes equipment and processing issues, and estimates environmental impacts from a life cycle analysis.
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U2 - 10.1007/s10098-011-0433-6
DO - 10.1007/s10098-011-0433-6
M3 - Article
AN - SCOPUS:84866024904
SN - 1618-954X
VL - 14
SP - 687
EP - 698
JO - Clean Technologies and Environmental Policy
JF - Clean Technologies and Environmental Policy
IS - 4
ER -