Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL

Keyphrases

• CHOP Pathway 100%
• Gossypol 100%
• Death Receptor 5 100%
• TRAIL-induced Apoptosis 27%
• Gene Silencing 18%
• Death Receptor 18%
• TRAIL Receptors 18%
• ERK2 9%
• Cancer Treatment 9%
• JNK Activation 9%
• Activity Assay 9%
• Esterase Activity 9%
• Decoy Receptor 9%
• Type-specific 9%
• G1 Cell Cycle Arrest 9%
• Pharmacological Agents 9%
• Apoptosis-inducing Activity 9%
• Caspase-8 9%
• P38 MAPK Activation 9%
• Human Colon Cancer Cells 9%
• Resistance Development 9%

Pharmacology, Toxicology and Pharmaceutical Science

• Colon Cancer 100%
• Gossypol 100%
• Death Receptor 5 100%
• Death Receptor 18%
• Tumor Necrosis Factor Related Apoptosis Inducing Ligand Receptor 18%
• Mitogen Activated Protein Kinase 3 9%
• Protein Bcl Xl 9%
• Small Interfering RNA 9%
• Caspase 8 9%
• Esterase 9%

Biochemistry, Genetics and Molecular Biology

• TRAIL 100%
• Colon 100%
• Gene Silencing 16%
• Esterase 8%
• P38 Mitogen-Activated Protein Kinases 8%
• Upregulation 8%
• Caspase 8 8%
• G1/S Transition 8%
• X-Linked Inhibitory Apoptosis Protein 8%