TY - JOUR
T1 - Glucose metabolism in the infant weighing less than 1100 grams
AU - Tyrala, Eileen E.
AU - Chen, Xinhua
AU - Boden, Guenther
N1 - Funding Information:
Supported by U.S. Public Health Service grants AG-07988 (G. Boden) and RR-349 (General Clinical Research Center) and a Clinical Research Grant from the American Diabetes Association (G. Boden)
PY - 1994/8
Y1 - 1994/8
N2 - We studied the rate of endogenous glucose production and disappearance in a group of 10 clinically stable <1100 gm infants in the first week of life, using stable-isotope (6,6-2H-glucose) dilution analysis for a 2-hour study period. Plasma glucose and insulin concentrations at 2 hours were 5.4 ± 2.5 mmol/L (97 ± 15 mg/dl) and 71.4 ± 2.9 pmol/L, respectively, and did not change during the study period. The rate of glucose disappearance was 37 ± 10 μmol/kg (6.77 ± 0.55 mg/kg) per minute. The rate of endogenous glucose production was 12.3 ± 11 μmol/kg (2.22 ± 0.61 mg/kg) per minute. The exogenous glucose infusion rate was 25.2 ± 8.4 μmol/kg (4.54 ± 0.47 mg/kg) per minute. Endogenous glucose production was correlated with plasma glucose concentration (r = 0.76; p < 0.05) and the rate of glucose disappearance (r = 0.75; p < 0.05); plasma glucose concentration was correlated with the rate of disappearance (r = 0.87; p = < 0.01) and insulin concentrations (p < 0.05). We conclude that infants who weigh <1100 gm utilize three to four times more glucose per kilogram of body weight than adults, reflecting their higher ratio of brain to body weight. Endogenous glucose production provided only approximately one third of the glucose needed-a mandate for the exogenous infusion of glucose to prevent the development of hypoglycemia. (J PEDIATR 1994;125:283-7).
AB - We studied the rate of endogenous glucose production and disappearance in a group of 10 clinically stable <1100 gm infants in the first week of life, using stable-isotope (6,6-2H-glucose) dilution analysis for a 2-hour study period. Plasma glucose and insulin concentrations at 2 hours were 5.4 ± 2.5 mmol/L (97 ± 15 mg/dl) and 71.4 ± 2.9 pmol/L, respectively, and did not change during the study period. The rate of glucose disappearance was 37 ± 10 μmol/kg (6.77 ± 0.55 mg/kg) per minute. The rate of endogenous glucose production was 12.3 ± 11 μmol/kg (2.22 ± 0.61 mg/kg) per minute. The exogenous glucose infusion rate was 25.2 ± 8.4 μmol/kg (4.54 ± 0.47 mg/kg) per minute. Endogenous glucose production was correlated with plasma glucose concentration (r = 0.76; p < 0.05) and the rate of glucose disappearance (r = 0.75; p < 0.05); plasma glucose concentration was correlated with the rate of disappearance (r = 0.87; p = < 0.01) and insulin concentrations (p < 0.05). We conclude that infants who weigh <1100 gm utilize three to four times more glucose per kilogram of body weight than adults, reflecting their higher ratio of brain to body weight. Endogenous glucose production provided only approximately one third of the glucose needed-a mandate for the exogenous infusion of glucose to prevent the development of hypoglycemia. (J PEDIATR 1994;125:283-7).
UR - http://www.scopus.com/inward/record.url?scp=0028128612&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028128612&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(94)70212-8
DO - 10.1016/S0022-3476(94)70212-8
M3 - Article
C2 - 8040779
AN - SCOPUS:0028128612
SN - 0022-3476
VL - 125
SP - 283
EP - 287
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
IS - 2
ER -