Glucose, foetal growth, and pregnancy

Xinhua Chen, Theresa O. Scholl

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2 Scopus citations


    Normal pregnancy is marked by significant changes in maternal insulin resistance and hyperinsulinaemia from progressively increasing insulin secretion during gestation. The regulation of glucose metabolism during pregnancy is complex. After a successful implantation of a genetically normal foetus, the placenta plays a critical role in the delivery of nutrients and in the tissue-specific regulation of normal foetal growth. In addition to its metabolic and endocrine function, the placenta secretes cytokines that significantly impact foetal growth. Pregnancies complicated by gestational diabetes mellitus (GDM) have an increased risk of foetal overgrowth (macrosomia or large for gestational age birth), higher perinatal morbidity and mortality, and presage a long-term risk of developing type 2 diabetes for the mother.

    Original languageEnglish (US)
    Title of host publicationGestational Diabetes
    Subtitle of host publicationOrigins, Complications, and Treatment
    PublisherCRC Press
    Number of pages30
    ISBN (Electronic)9781439879979
    ISBN (Print)9781439879962
    StatePublished - Jan 1 2014

    All Science Journal Classification (ASJC) codes

    • Medicine(all)

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