Glucose, foetal growth, and pregnancy

Xinhua Chen, Theresa O. Scholl

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Normal pregnancy is marked by significant changes in maternal insulin resistance and hyperinsulinaemia from progressively increasing insulin secretion during gestation. The regulation of glucose metabolism during pregnancy is complex. After a successful implantation of a genetically normal foetus, the placenta plays a critical role in the delivery of nutrients and in the tissue-specific regulation of normal foetal growth. In addition to its metabolic and endocrine function, the placenta secretes cytokines that significantly impact foetal growth. Pregnancies complicated by gestational diabetes mellitus (GDM) have an increased risk of foetal overgrowth (macrosomia or large for gestational age birth), higher perinatal morbidity and mortality, and presage a long-term risk of developing type 2 diabetes for the mother.

Original languageEnglish (US)
Title of host publicationGestational Diabetes
Subtitle of host publicationOrigins, Complications, and Treatment
PublisherCRC Press
Number of pages30
ISBN (Electronic)9781439879979
ISBN (Print)9781439879962
StatePublished - Jan 1 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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