Gesteuerte vertikale knochen - regeneration durch raue und alkalisierte implantatoberflächen

Introduction: To determine if an alkaline surface treatment would enhance vertical bone growth around sand-blasted, large grit, acid-etched (SLA) titanium implants in a rabbit mandible model. Material and methods: A total of twelve New Zealand white rabbits received either SLA or alkaline-treated SLA implants placed in transverse orientation in the posterior mandible with the coronal 3 mm of the implants left outside the bone. Three treatment groups (n = 6 implants per group) were studied with or without demineralized bone matrix (DBM) scaffolds as follows: SLA/DBM, alkSLA/DBM or alkSLA alone. The DBM was stabilized by a scaffold retention screw. MicroCT imaging and histological analysis was performed on retrieved specimens after ten weeks of healing to assess new bone formation. Results: For all parameters, except for bone volume fraction, the highest values were recorded for SLA implants plus DBM scaffolds. Bone-to-implant contact (BIC) in the newlyformed mass of bone above the original bone was not enhanced in the alkaline-treated group as compared to the SLA group (32.0 % ± 13.5 vs. 55.7 % ± 12.8; p = 0.0152). Significantly less new bone formed around alkaline-treated implants when they were placed without DBM scaffolds (e. g. bone height with DBM: 1.9 mm ± 0.3, without DBM: 0.3 mm ± 0.5; p = 0.0312). Discussion: Alkaline treatment of commercially available SLA implants did not enhance vertical bone regeneration or bone-to-implant contact in combination with DBM in this animal model.