Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence

Falk W. Lohoff, Paul J. Bloch, Andrew E. Weller, Aleksandra H. Nall, Glenn A. Doyle, Russell J. Buono, Thomas N. Ferraro, Kyle M. Kampman, Helen M. Pettinati, Charles A. Dackis, David W. Oslin, Charles P. O'Brien, Wade H. Berrettini

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Dopaminergic brain systems have been implicated to play a major role in drug reward, thus making genes involved in these circuits plausible candidates for susceptibility to substance use disorders. The cocaine- and amphetamine-regulated transcript peptide (CARTPT) is involved in reward and feeding behavior and has functional characteristics of an endogenous psychostimulant. In this study we tested the hypothesis that variation in the CARTPT gene increases susceptibility to cocaine dependence in individuals of African descent. Genotypes of three HapMap tagging SNPs (rs6894758; rs11575893; rs17358300) across the CARTPT gene region were obtained in cocaine dependent individuals (n = 348) and normal controls (n = 256). All subjects were of African descent. There were no significant differences in allele, genotype or haplotype frequencies between cases and controls for any of the tested SNPs. Our results do not support an association of the CARTPT gene with cocaine dependence; however, additional studies using larger samples, comprehensive SNP coverage, and different populations are necessary to conclusively rule out CARTPT as a contributing factor in the etiology of cocaine dependence.

Original languageEnglish (US)
Pages (from-to)280-283
Number of pages4
JournalNeuroscience Letters
Volume440
Issue number3
DOIs
StatePublished - Aug 8 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience

Fingerprint

Dive into the research topics of 'Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence'. Together they form a unique fingerprint.

Cite this