Ganglioside stimulation of axonal sprouting in vitro

Fred J. Roisen, Harry Bartfeld, Robert Nagele, Glee Yorke

Research output: Contribution to journalArticlepeer-review

303 Scopus citations

Abstract

Bovine brain gangliosides were applied to primary and established neuronal cultures to examine the role of gangliosides in neuronal development. Media containing gangliosides enhanced the degree of axonal elongation exhibited by sensory ganglia neurons and increased the length and number of Neuro-2a neuroblastoma cell processes. Ganglioside-supplemented media caused a twofold increase in ornithine decarboxylase activity in both culture systems. These experiments suggest that gangliosides function as acceptor molecules for growth-promoting substances in embryonic and tumor-derived neurons.

Original languageEnglish (US)
Pages (from-to)577-578
Number of pages2
JournalScience
Volume214
Issue number4520
DOIs
StatePublished - 1981

All Science Journal Classification (ASJC) codes

  • General

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