Ganglioside stimulation of axonal sprouting in vitro

Fred J. Roisen; Harry Bartfeld; Robert Nagele; Glee Yorke

doi:10.1126/science.7291999

Ganglioside stimulation of axonal sprouting in vitro

Fred J. Roisen, Harry Bartfeld, Robert Nagele, Glee Yorke

Research output: Contribution to journal › Article › peer-review

317 Scopus citations

Abstract

Bovine brain gangliosides were applied to primary and established neuronal cultures to examine the role of gangliosides in neuronal development. Media containing gangliosides enhanced the degree of axonal elongation exhibited by sensory ganglia neurons and increased the length and number of Neuro-2a neuroblastoma cell processes. Ganglioside-supplemented media caused a twofold increase in ornithine decarboxylase activity in both culture systems. These experiments suggest that gangliosides function as acceptor molecules for growth-promoting substances in embryonic and tumor-derived neurons.

Original language	English (US)
Pages (from-to)	577-578
Number of pages	2
Journal	Science
Volume	214
Issue number	4520
DOIs	https://doi.org/10.1126/science.7291999
State	Published - 1981
Externally published	Yes

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10.1126/science.7291999

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title = "Ganglioside stimulation of axonal sprouting in vitro",

abstract = "Bovine brain gangliosides were applied to primary and established neuronal cultures to examine the role of gangliosides in neuronal development. Media containing gangliosides enhanced the degree of axonal elongation exhibited by sensory ganglia neurons and increased the length and number of Neuro-2a neuroblastoma cell processes. Ganglioside-supplemented media caused a twofold increase in ornithine decarboxylase activity in both culture systems. These experiments suggest that gangliosides function as acceptor molecules for growth-promoting substances in embryonic and tumor-derived neurons.",

author = "Roisen, {Fred J.} and Harry Bartfeld and Robert Nagele and Glee Yorke",

year = "1981",

doi = "10.1126/science.7291999",

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pages = "577--578",

journal = "Science",

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TY - JOUR

T1 - Ganglioside stimulation of axonal sprouting in vitro

AU - Roisen, Fred J.

AU - Bartfeld, Harry

AU - Nagele, Robert

AU - Yorke, Glee

PY - 1981

Y1 - 1981

N2 - Bovine brain gangliosides were applied to primary and established neuronal cultures to examine the role of gangliosides in neuronal development. Media containing gangliosides enhanced the degree of axonal elongation exhibited by sensory ganglia neurons and increased the length and number of Neuro-2a neuroblastoma cell processes. Ganglioside-supplemented media caused a twofold increase in ornithine decarboxylase activity in both culture systems. These experiments suggest that gangliosides function as acceptor molecules for growth-promoting substances in embryonic and tumor-derived neurons.

AB - Bovine brain gangliosides were applied to primary and established neuronal cultures to examine the role of gangliosides in neuronal development. Media containing gangliosides enhanced the degree of axonal elongation exhibited by sensory ganglia neurons and increased the length and number of Neuro-2a neuroblastoma cell processes. Ganglioside-supplemented media caused a twofold increase in ornithine decarboxylase activity in both culture systems. These experiments suggest that gangliosides function as acceptor molecules for growth-promoting substances in embryonic and tumor-derived neurons.

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SP - 577

EP - 578

JO - Science

JF - Science

IS - 4520

ER -

Ganglioside stimulation of axonal sprouting in vitro

Abstract

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