@article{3cbfc95f4f3c4ba0b04d2fdee8e8489e,
title = "From Heterocycles to Carbacycles: Synthesis of Carbocyclic Nucleoside Analogues from Enals and Hydroxylamines",
abstract = "Substituted and stereochemically dense carbacycles can be prepared by sequential dipolar cycloaddition and reductive cleavage from enals and hydroxylamines. The reaction sequence proceeds with high efficiency for a wide variety of enals and hydroxylamines. The reaction is regio- and diastereoselective for the initial formation of a bridged bisisoxazolidine intermediate, which then undergoes quantitative double N-O cleavage to produce carbacycles as single diastereomers.",
author = "Pulakesh Das and Almond, {David W.} and Tumbelty, {Lauren N.} and Austin, {Brooke E.} and Gustavo Moura-Letts",
note = "Funding Information: This material is based on work supported by the National Science Foundation CAREER and MRI awards under grant numbers CHE-1752085 and CHE-1827938, respectively. We thank Professor Erik Hoy (Rowan University, Department of Chemistry and Biochemistry) for his help with the relative stability calculations and Dr. Phil Jeffrey (Princeton University, Department of Chemistry) for X-ray crystallography experiments. Publisher Copyright: {\textcopyright} 2020 American Chemical Society.",
year = "2020",
month = jul,
day = "17",
doi = "10.1021/acs.orglett.0c01846",
language = "English (US)",
volume = "22",
pages = "5491--5495",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "14",
}