Flexible and disposable immunosensors based on layer-bylayer self-assembled carbon nanotubes and biomolecules

Miao Lu, Dongjin Lee, Wei Xue, Tianhong Cui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

A low-cost, flexible, and disposable immunosensor is presented in this paper. The single-walled carbon nanotubes (SWNT) and biomolecules are self-assembled on micro patterned electrodes. The immuno-chip acts as the platform of a horseradish peroxidase (HRP) labeled sandwiched Enzyme-Linked ImmunoSorbent Assay (ELISA). The pH change induced by the biochemical reactions influences the electrical conductance of SWNT. The detection resolution of 0.4 ng/ml (2.5 pM) for normal rabbit immunoglobulin G (IgG) is demonstrated. The new fabrication technique and the HRP labeled detection protocol can be extended to the recognition of other antigens for critical applications to clinical diagnosis, food toxin detection, and environment monitoring, etc.

Original languageEnglish (US)
Title of host publicationMEMS 2008 Tucson - 21st IEEE International Conference on Micro Electro Mechanical Systems
Pages188-191
Number of pages4
DOIs
StatePublished - Aug 29 2008
Event21st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2008 Tucson - Tucson, AZ, United States
Duration: Jan 13 2008Jan 17 2008

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Other

Other21st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2008 Tucson
CountryUnited States
CityTucson, AZ
Period1/13/081/17/08

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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