FISH OIL FEEDING SELECTIVELY ATTENUATES CONTRACTILE RESPONSES TO NORADRENALINE AND ELECTRICAL STIMULATION IN THE PERFUSED MESENTERIC RESISTANCE VESSELS OF SPONTANEOUSLY HYPERTENSIVE RATS

Z. M. Chu, Kingsley Yin, L. J. Beilin

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

1. The mechanism of the antihypertensive effects of n‐3 fatty acids were examined in spontaneously hypertensive rats (SHR) by feeding ‘Max EPA’ fish oil or hydrogenated coconut oil and determining the responses of perfused mesenteric resistance vessels to various contractile agents and peri‐arterial nerve stimulation. 2. Fish oil feeding for 4 weeks caused a decrease in the responses to exogenous noradrenaline and electrical nerve stimulations but had no significant effect on vasopressin and KC1 (80 mmol/L) induced contractions. 3. These results provide direct evidence for specific attenuation of vascular responses to sympatho‐adrenal stimulation in resistance vessels following fish oil feeding and may account for the antihypertensive effects seen in humans and in some forms of hypertension in rats.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume19
Issue number3
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

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