First total synthesis of the macrophage derived anti-inflammatory and pro-resolving lipid mediator Maresin 2

Ana R. Rodriguez; Bernd W. Spur

doi:10.1016/j.tetlet.2014.11.082

First total synthesis of the macrophage derived anti-inflammatory and pro-resolving lipid mediator Maresin 2

Ana R. Rodriguez, Bernd W. Spur

Cell Biology

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19 Scopus citations

Abstract

The first total synthesis of the potent anti-inflammatory lipid mediator Maresin 2 derived from docosahexaenoic acid, has been achieved. The chiral hydroxy-groups at C13 and C14 were obtained via a chiral pool strategy from 3,4-O-isopropylidene-2-deoxy-d-ribose. Wittig reactions and acetonide cleavage followed by mild ester hydrolysis afforded Maresin 2.

Original language	English (US)
Pages (from-to)	256-259
Number of pages	4
Journal	Tetrahedron Letters
Volume	56
Issue number	1
DOIs	https://doi.org/10.1016/j.tetlet.2014.11.082
State	Published - Jan 1 2015

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2014.11.082

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abstract = "The first total synthesis of the potent anti-inflammatory lipid mediator Maresin 2 derived from docosahexaenoic acid, has been achieved. The chiral hydroxy-groups at C13 and C14 were obtained via a chiral pool strategy from 3,4-O-isopropylidene-2-deoxy-d-ribose. Wittig reactions and acetonide cleavage followed by mild ester hydrolysis afforded Maresin 2.",

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First total synthesis of the macrophage derived anti-inflammatory and pro-resolving lipid mediator Maresin 2

Abstract

All Science Journal Classification (ASJC) codes

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