First total synthesis of 7(S),16(R),17(S)-Resolvin D2, a potent anti-inflammatory lipid mediator

Ana R. Rodríguez, Bernd W. Spur

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

A total synthesis of a biological highly active lipid mediator derived from docosahexaenoic acid is described. The first total synthesis of 7(S),16(R),17(S)-Resolvin D2, a lipid mediator derived from docosahexaenoic acid, has been achieved. The key features of our synthetic strategy encompass a Co-salen hydrolytic kinetic resolution of a terminal epoxide combined with a chiral pool strategy.

Original languageEnglish (US)
Pages (from-to)8717-8720
Number of pages4
JournalTetrahedron Letters
Volume45
Issue number47
DOIs
StatePublished - Nov 15 2004

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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